Purpose: Differences in core and veneer coefficients of thermal expansion, firing shrinkage, and speed of increasing and decreasing the temperature may generate stress in veneered all-ceramic restorations. Given the necessity of performing multiple firing cycles to achieve improved contour, color, and esthetics, the purpose of this study was to determine the effect of multiple firing cycles on the microtensile bond strength (MTBS) of zirconia core to the porcelain veneer in zirconia-based all-ceramic restorations.
Materials And Methods: Thirty blocks (12 × 12 × 4 mm(3)) of semi-sintered zirconia were machined and sintered according to manufacturer's instruction. Specimens were placed in three groups based on the number of firing cycles (4, 6, 8) for the veneering process. After veneering, the specimens were sectioned into microbars with 8 mm length and 1 mm cross-section. Twenty sound microbars in each group were stressed to failure in a microtensile tester machine at 1 mm/min. Fractured specimens were surveyed under a scanning electron microscope and classified as cohesive in core, cohesive in veneer, and mixed. MTBS data were analyzed using one-way ANOVA and Tukey test (p < 0.05).
Results: The mean MTBS (MPa) after 4, 6, and 8 firing cycles were 30.33 ± 2.13, 27.43 ± 1.79, and 25.06 ± 1.76, respectively. There was a statistically significant difference between the bond strengths of each of the three groups (p < 0.001).
Conclusion: Increase in firing cycles decreased MTBS. Most of the failures (90-95%) in all three groups were cohesive in the veneering porcelain and did not change as the number of firing cycles increased.
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http://dx.doi.org/10.1111/j.1532-849X.2012.00889.x | DOI Listing |
Invest New Drugs
January 2025
UCD School of Medicine, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland.
Background: Since MYC is one of the most frequently altered driver genes involved in cancer formation, it is a potential target for new anti-cancer therapies. Historically, however, MYC has proved difficult to target due to the absence of a suitable crevice for binding potential low molecular weight drugs.
Objective: The aim of this study was to evaluate a novel molecular glue, dubbed GT19630, which degrades both MYC and GSPT1, for the treatment of breast cancer.
Environ Res
January 2025
School of Environmental Science and Engineering, Guangzhou University, Guangzhou, 510006, PR. China; Guangzhou University-Linköping University Research Center on Urban Sustainable Development, Guangzhou University, Guangzhou 510006, PR. China. Electronic address:
Antimony (Sb) contamination in water resources poses a critical environmental and health challenge globally. Sulfate reducing bacteria (SRB) are employed to reduce SO to S for removing Sb in a microbial electrolysis cell (MEC). Yet, the reduction efficiency of reducing SO and Sb(Ⅴ) through SRB remains relatively low, and the underlying mechanism remains elusive.
View Article and Find Full Text PDFiScience
January 2025
Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zürich, Vladimir-Prelog-Weg 1, 8093 Zürich, Switzerland.
In 2022, the European Union put forward the REPowerEU plan in response to Russia's invasion of Ukraine, aiming at enhancing short-term energy security by diversifying imports and reducing natural gas demand while accelerating the deployment of renewable alternatives in the long term. Here, we quantify the life cycle environmental impacts of both REPowerEU's short-term measures, including the controversial extended coal-fired power plant operations, and how the first year of the crisis was managed in practice. We find that the policy measures' impact on greenhouse gas (GHG) emissions would be negligible, although they could have detrimental effects on other environmental categories.
View Article and Find Full Text PDFHeliyon
January 2025
School of Business and Management, Institute of Technology Bandung (ITB), Bandung, Indonesia.
This study aims to integrate short-term, medium-term, and long-term Composite Leading Indices (CLIs) to establish that interconnected CLIs offer enhanced predictive capabilities compared to individual CLIs. Specifically, it investigates the relationships among CLIs to forecast Indonesia's Manufacturing Cycle (ManC) using Partial Least Squares-Structural Equation Modeling (PLS-SEM). Building on an extensive literature review, the study employs quarterly data spanning from Q1 2010 to Q2 2022, incorporating five constructs representing key economic sectors influencing the manufacturing cycle.
View Article and Find Full Text PDFVitam Horm
January 2025
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Ciudad Autónoma de Buenos Aires, Argentina; Centro de Estudios Biomédicos Básicos, Aplicados y Desarrollo (CEBBAD), Universidad Maimónides, Ciudad Autónoma de Buenos Aires, Argentina. Electronic address:
Light is the most reliable environmental cue allowing animals to breed successfully when conditions are optimal. In seasonal breeders, photoperiod (length of daylight) information is sensed by the eyes and transmitted to the suprachiasmatic nucleus, the master clock region located in the hypothalamus. This structure has a 24-h firing rhythm involving a cycle of clock protein synthesis and degradation, and provides the timing to synchronize the synthesis and release of melatonin, the chemical signal that transduces the photoperiod information.
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