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| http://dx.doi.org/10.1155/2012/432590 | DOI Listing |
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Analyzing the functions of Translationally controlled tumor protein2 during growth, development and autophagy of Dictyostelium discoideum.
Exp Cell Res
January 2025
School of Life Sciences, Jawaharlal Nehru University, New Delhi-110067, India. Electronic address:
Translationally controlled tumor protein (TCTP) is a well conserved and ubiquitously expressed multifunctional protein found in many organisms and is involved in many pathophysiological processes like cell proliferation, differentiation, development and cell death. The role of TCTP in anti-apoptosis and cancer metastasis makes it a promising candidate for cancer therapy. Dictyostelium discoideum, a protist, has two isoforms (TCTP1 and TCTP2, now referred to as TPT1 and TPT2) of which we have earlier elucidated TPT1.
View Article and Find Full Text PDFDevelopment of a molecular assay for the determination of Eimeria tenella oocyst viability.
Parasitol Res
December 2024
Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada.
Coccidiosis is caused by apicomplexan parasites of the genus Eimeria, which infect epithelial cells of the intestinal tract causing diarrhea and negatively impacting production in the poultry industry. The self-limiting and highly immunogenic nature of infection by Eimeria spp. make live vaccination an effective means of coccidiosis control.
View Article and Find Full Text PDFDistribution of the p66Shc Adaptor Protein Among Mitochondrial and Mitochondria-Associated Membranes Fractions in Normal and Oxidative Stress Conditions.
Int J Mol Sci
November 2024
Laboratory of Mitochondrial Biology and Metabolism, Nencki Institute of Experimental Biology of Polish Academy of Sciences, 02-093 Warsaw, Poland.
Article Synopsis
- - p66Shc is an adaptor protein crucial for regulating cellular functions including signaling pathways, mitochondrial activity, and the production of reactive oxygen species (ROS), with its location shifting to mitochondria under oxidative stress.
- - The protein is also implicated in mitochondria-associated membranes (MAM), which play a role in key cellular processes like calcium balance, apoptosis (cell death), and autophagy (cell cleaning), suggesting p66Shc's involvement in determining cell fate.
- - This study investigates the distribution of p66Shc in different parts of mouse liver tissue and HepG2 cells, demonstrating a significant presence of p66Shc in MAM under both normal and oxidative stress conditions.
Translationally Controlled Tumor Protein Enhances Angiogenesis in Ovarian Tumors by Activating Vascular Endothelial Growth Factor Receptor 2 Signaling.
Biomol Ther (Seoul)
January 2025
College of Pharmacy, Dongguk University, Goyang 10326, Republic of Korea.
Translationally controlled tumor protein (TCTP) is a regulatory protein that plays pivotal roles in cellular processes including the cell cycle, apoptosis, microtubule stabilization, embryo development, stress responses, and cancer. However, the molecular mechanism by which it promotes tumor angiogenesis is still unclear. In this study, we explored the mechanisms underlying stimulation of angiogenesis by a novel TCTP.
View Article and Find Full Text PDFExploring multivalency-driven sensitivity modulation for optimization and fine-tuning of avidity-based biosensors.
Biosens Bioelectron
March 2025
Department of Biochemistry, Kangwon National University, Chuncheon, 24341, South Korea; Institute of Life Sciences (ILS), Kangwon National University, Chuncheon, 24341, South Korea; Global/Gangwon Innovative Biologics-Regional Leading Research Center (GIB-RLRC), Kangwon National University, Chuncheon, 24341, South Korea. Electronic address:
The development of multivalent nanoprobes has garnered considerable interest due to their enhanced sensitivity and precision in diagnosing and monitoring diverse diseases. Despite significant advances in nanobiotechnology, the optimal density of binding motifs to maximize the diagnostic efficacy of biosensors remains incompletely understood. Herein, we investigate the influence of multivalency in the functional performance of avidity-based biosensors.
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