Purpose: To compare the anesthetic induction time (IT) in the first and second surgery in rabbits.
Methods: Eighteen rabbits, weighing between 1.825 and 2.980 kg. The anesthetic protocol consisted of premedication of ketamine and xylazine intramuscularly. The rabbits were anesthetized and the induction time was evaluated by compressing the animal's ear every 30 seconds. The IT was measure and than a saphenous vein surgery was made on the rabbit. Seven days after the first procedure, the same anesthetic protocol was performed and measuring the second IT.
Results: It was observed an increase of 50 seconds on the average value of second IT in relation to the average value of first. The IT variation between the first and second anesthetic procedure was between 0 and eight minutes for each animal. In 94.4% of the animals, there was variation greater than 30 seconds between the IT.
Conclusion: There was difference between the first and second induction time in almost animals. There was an increase on the average value of second IT in relation to the average value of first.
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http://dx.doi.org/10.1590/s0102-86502012000700009 | DOI Listing |
Drug Des Devel Ther
January 2025
Department of Anesthesiology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, Nanchang, Jiangxi, 330006, People's Republic of China.
Background: Ciprofol, a novel intravenous anesthetic derived from propofol, exhibits high lipophilicity. Its pharmacokinetics and pharmacodynamics may vary across different body mass indices (BMI) categories, but data on its optimal dosing as well as its safety and efficacy during colonoscopy anesthesia in varying BMI groups are lacking.
Objective: To evaluate the efficacy and safety of ciprofol during anesthesia for painless colonoscopy in patients with varying BMI, and to explore the correlation between BMI and induction dose.
Discov Med (Cham)
January 2025
Institute of Biomedical Engineering, University of Toronto, Toronto, ON Canada.
Background: Microvascular dysfunction (MVD) is a recognized sign of disease in heart failure progression. Intact blood vessels exhibit abnormal vasoreactivity in early stage, subsequently deteriorating to rarefaction and reduced perfusion. In managing heart failure with preserved ejection fraction (HFpEF), earlier diagnosis is key to improving management.
View Article and Find Full Text PDFBMC Anesthesiol
January 2025
Department of Anesthesiology, Air Force Medical Center, No.30 Fucheng Road, Haidian District, Beijing, 100142, China.
Background: Sufentanil is commonly used to induce general anaesthesia due to its rapid onset of action, strong analgesic effect, long-lasting effect, and stable haemodynamics; however, it often induces cough, increasing the risk of anaesthesia. This study aimed to investigate the preventive effect of low-dose esketamine on sufentanil-induced cough.
Methods: This randomised, double-blind, placebo-controlled clinical study was conducted at the Air Force Medical Center between September 2023 and May 2024.
Int J Biol Macromol
January 2025
State Key Laboratory of Materials-Oriented Chemical Engineering, Collogue of Chemical Engineering, Nanjing Tech University, Nanjing 211816, PR China. Electronic address:
In this study, demethylated-acylated enzymatic hydrolysis lignin (DAEHL) with excellent solubility in castor oil and antioxidant activities were prepared via the tandem modification strategy. First, iodocyclohexane simultaneously achieved β-O-4 breakage and hydrogenation, which enhanced the antioxidant activity of lignin. Furthermore, the acylation reaction by palmitoyl chloride increased the alkyl content in the lignin, which can improve the solubility of lignin in castor oil.
View Article and Find Full Text PDFKorean J Intern Med
January 2025
Department of Hematology/Oncology, Kyungpook National University Hospital, School of Medicine, Kyungpook National University, Daegu, Korea.
Background/aims: To determine the effectiveness of tyrosine kinase inhibitor (TKI) plus reduced-intensity therapy in adult patients with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph-positive ALL), this retrospective study compared treatment outcomes and induction mortality according to backbone regimen intensity.
Methods: The data of 132 patients diagnosed with Ph-positive ALL were retrospectively collected from five centers. Patients received imatinib plus intensive chemotherapy (modified VPD, KALLA1407, or hyper-CVAD) or reduced-intensity chemotherapy (EWALL) for curative purposes.
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