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| http://dx.doi.org/10.1007/s11999-012-2416-2 | DOI Listing |
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Is there an Increase in Total Hip Arthroplasty Due to Osteonecrosis of Femoral Head After Covid-19 Pandemic?: A Retrospective Study Among Patients in Central Karnataka, India.
J Orthop Case Rep
January 2025
Department of Orthopaedics, Srinivas Institute of Medical Science and Research Centre, Mangaluru, Karnataka, India.
Introduction: Coronavirus disease 2019 (COVID-19) infection or corticosteroid usage during the COVID-19 pandemic as risk factors for avascular necrosis (AVN) of the femoral head (osteonecrosis of the femoral head/femoral head AVN [FHAVN]), as well as its link to clinical and radiological outcomes, are poorly understood. Osteonecrosis, which results from a disruption in vascular supply to the femoral head, is a prevalent cause of hip joint deterioration and one of the most common reasons for total hip arthroplasty (THA)/total hip replacement in India and other Asian countries. This study will aid in understanding the condition's epidemiology and statistically determining the risk of disease related with pandemic exposure.
View Article and Find Full Text PDFExosomes secreted from human-derived adipose stem cells prevent progression of osteonecrosis of the femoral head.
J Orthop Surg Res
November 2024
Department of Orthopaedic Surgery, Kyoto University Graduate School of Medicine, Sakyo, Kyoto, 606- 8507, Japan.
Article Synopsis
- Osteonecrosis of the femoral head (ONFH) primarily impacts younger individuals and is a major reason for hip replacement surgeries in this demographic; new regenerative therapies like core decompression (CD) combined with exosomes from human adipose stem cells (hADSC) show promise but need more research to validate their effectiveness.
- The study involved extracting and characterizing hADSC-derived exosomes and testing their protective effects on ONFH in a rabbit model induced by surgical vascular occlusion and corticosteroid injections; the rabbits were divided into an exosome treatment group and a control group receiving saline.
- Results indicated that the group treated with hADSC-derived exosomes experienced significantly less severe progression of ONFH compared to the control group
The Application of Magnetic Resonance Imaging in the Early and Accurate Diagnosis of Hip Joint Avascular Necrosis.
Cureus
September 2024
Radiodiagnosis, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed to be University), Pune, IND.
Article Synopsis
- Avascular necrosis (AVN) is the death of bone tissue due to disrupted blood supply, often seen in the femoral head, and this study investigates MRI's role in diagnosing it early.
- Conducted at a hospital in India, the research analyzed 30 patients with hip pain, comparing diagnoses made via plain radiographs and MRI; MRI correctly identified AVN in all cases, while radiographs missed many.
- The study concludes that relying only on X-rays can overlook critical stages of AVN; MRI is superior in detecting the condition early due to its advanced imaging capabilities.
Risk Factors for Femoral Head Collapse in Osteonecrosis.
J Arthroplasty
September 2024
Department of Orthopaedic Surgery, University of Southern California Keck School of Medicine, Los Angeles, California.
Article Synopsis
- Osteonecrosis of the femoral head (ONFH) affects over 20,000 individuals in the U.S. annually, yet the mechanisms behind its progression are not well understood, prompting research into various contributing factors.
- A study was conducted on 105 ONFH patients to evaluate risk factors, femoral head anatomy, and necrotic lesion size, utilizing multivariable regression to identify predictors of femoral head collapse.
- Findings revealed that alcohol exposure, a larger necrotic lesion, and higher alpha angles increased the risk of collapse, while greater femoral head offset appeared to protect against it; the study emphasizes the need for larger future studies to further investigate these relationships.
[Avascular necrosis of the femoral head after COVID-19: clinical presentation and management. Clinical-functional outcomes of decompression and supplementation with bone marrow cell aspirate].
Acta Ortop Mex
September 2024
Hospital San Rafael, Hospitales Pascual. Cádiz, España.
Introduction: the pandemic of COVID-19 has led to clinical complications such as avascular necrosis of the femoral head (AVNFH) associated with the use of corticosteroids. The aim of the study is to report the functional and radiographic results of 13 patients with post-COVID-19 ANFH after decompression using Forage and bone marrow aspirate concentrate (BMAC).
Material And Methods: single-center, prospective, uncontrolled clinical study.
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