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Effects of Caffeic Acid Phenethyl Ester on Embryonic Development Through Regulation of Mitochondria and Endoplasmic Reticulum.
Vet Sci
December 2024
Guangdong Provincial Key Laboratory of Large Animal Models for Biomedicine, South China Institute of Large Animal Models for Biomedicine, School of Pharmacy and Food Engineering, Wuyi University, Jiangmen 529000, China.
Caffeic acid phenethyl ester (CAPE) is one of the main active components of the natural medicine propolis, which has antioxidant, anti-tumor, and immunomodulatory activities. This study aimed to analyze the effects and underlying mechanisms of CAPE added to the medium of in vitro cultures on the developmental competence, mitochondria, and endoplasmic reticulum of porcine embryos. The results demonstrated that 1 nM of CAPE significantly improved the quality of porcine embryos, increased the rate of blastocyst formation, and enhanced the proliferation ability.
View Article and Find Full Text PDFMitochondrial homeostatic imbalance-mediated developmental toxicity to HS in embryonic zebrafish.
Environ Pollut
December 2024
Institute of Life Sciences & Biomedicine Collaborative Innovation Center of Zhejiang Province, College of Life and Environmental Science, Wenzhou University, Wenzhou, 325035, China. Electronic address:
Hydrogen sulfide (HS) is a pervasive environmental and industrial pollutant that poses a substantial threat to human health. Even short-term exposure to HS can result in severe respiratory and neurological damage. However, the underlying mechanisms of its biotoxicity remain unclear.
View Article and Find Full Text PDFOTUD5 Protects Dopaminergic Neurons by Promoting the Degradation of α-Synuclein in Parkinson's Disease Model.
Adv Sci (Weinh)
December 2024
Department of Pharmacology, School of Basic Medical Sciences, Shandong University, Jinan, Shandong, 250012, P. R. China.
Defective clearance and accumulation of α-synuclein (α-Syn) is the key pathogenic factor in Parkinson's disease (PD). Recent studies emphasize the importance of E3 ligases in regulating the degradation of α-Syn. However, the molecular mechanisms by which deubiquitinases regulate α-Syn degradation are scarcely studied.
View Article and Find Full Text PDFHippo-YAP signaling alleviates copper-induced mitochondrial dysfunction and oxidative damage via the ATOX1-PPA2 pathway.
Int J Biol Macromol
December 2024
Laboratory of Animal Developmental Biology, College of Life Science, Northeast Forestry University, Harbin 150040, China. Electronic address:
Hippo signaling plays a crucial role in the cellular response to various stressors, such as mechanical stress, metabolic stress, and hypoxic stress. However, its physiological significance in copper (Cu) stress remains poorly understood. Here, we demonstrated aberrant activation of Hippo-YAP signaling in sheep pancreas and pancreatic organoids exposed to excessive Cu, accompanied by significant pathological changes, elevated levels of oxidative stress, and impaired mitochondrial structure and function.
View Article and Find Full Text PDFCaregiver-centric interventions for family carers of children with neurodevelopmental disorders in India - A scoping review.
J Educ Health Promot
October 2024
Department of Social Sciences, School of Social Sciences and Languages, Vellore Institute of Technology, Vellore, Tamil Nadu, India.
Caregiving for children with neurodevelopment disorders (NDDs) can be a lifelong process that takes hold of an individual's time, energy, and resources. This raises a question about the caregivers' needs and concerns and the extent to which they receive medical or psychological attention during caregiving. This scoping review examines the psychosocial interventions conducted in India for caregivers of children with NDDs.
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