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Extracellular matrix stiffness regulates colorectal cancer progression via HSF4.
J Exp Clin Cancer Res
January 2025
Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Background: Colorectal cancer (CRC) has high incidence and mortality rates, with severe prognoses during invasion and metastasis stages. Despite advancements in diagnostic and therapeutic technologies, the impact of the tumour microenvironment, particularly extracellular matrix (ECM) stiffness, on CRC progression and metastasis is not fully understood.
Methods: This study included 107 CRC patients.
Exploring the Association Between Overactive Bladder (OAB) and Cognitive decline: mediation by depression in elderly adults, a NHANES weighted analysis.
Sci Rep
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School of Government, University of International Business and Economics, Chaoyang District, Beijing, 100029, P. R. China.
Overactive bladder (OAB) is a prevalent condition among older adults and may be linked to cognitive health. This study explored a relationship between OAB and cognitive health among adults aged 60 ≥ years in the United States, using NHANES 2011-2014. A cross-sectional analysis was conducted using a nationally representative sample of 2,324 (45.
View Article and Find Full Text PDFBimetallic FeCo phosphide-enabled electrochemical sensor for rapid tanshinol quantification in Salvia miltiorrhiza herb at near-neutral condition.
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School of Pharmaceutical Sciences, Key Laboratory of Innovative Drug Development and Evaluation, Hebei Medical University, Shijiazhuang, 050017, China. Electronic address:
Tanshinol, an active ingredient extracted from the Salvia miltiorrhiza herb, is widely used in Chinese medicine or health supplements. Accurately and rapidly quantifying of tanshinol under near-neutral or neutral conditions is of great significance but still a significant challenge. Herein, a novel electrochemical sensor based on bimetallic FeCo phosphides (FeCoP) was developed for rapid and sensitive detection of tanshinol in near-neutral environments.
View Article and Find Full Text PDFHigh-resolution groundwater storage anomalies in the Middle and Lower Yangtze River Basin of China using machine learning fusion of in-situ wells, satellite gravity and hydrological model.
J Environ Manage
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Hubei Subsurface Multi-scale Imaging Key Laboratory, School of Geophysics and Geomatics, China University of Geosciences, Wuhan, China.
Groundwater plays a key role in the water cycle and is used to meet industrial, agricultural, and domestic water demands. High-resolution modeling of groundwater storage is often challenging due to the limitations of observation techniques and mathematical methods. In this study, two machine learning (ML) algorithms, namely random forest (RF) and artificial neural networks (ANNs), were employed to estimate groundwater level anomaly (GWLA) and groundwater storage anomaly (GWSA) with a 0.
View Article and Find Full Text PDFCosts and characteristics of admissions due to ambulatory care-sensitive conditions in children under one year of age in São Paulo, Brazil.
Cien Saude Colet
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Departamento de Odontologia Social, Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas. Campinas SP Brasil.
This research aimed to estimate the direct costs and analyze the epidemiological aspects of ambulatory care-sensitive conditions (ACSC) in children under one year of age, São Paulo municipality, 2011-2022. Total and average costs were calculated according to ACSC diagnosis groups by components (early neonatal, late neonatal, and post-neonatal). The trend in ACSC rates was analyzed using Prais-Winsten generalized linear regression.
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