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Advancements in Cancer Treatment: Harnessing the Synergistic Potential of Graphene-Based Nanomaterials in Combination Therapy.
ACS Appl Mater Interfaces
January 2025
Surface Chemistry Research Laboratory, Faculty of Chemistry, Iran University of Science and Technology, Tehran 16846-13114, Iran.
Combination therapy, which involves using multiple therapeutic modalities simultaneously or sequentially, has become a cornerstone of modern cancer treatment. Graphene-based nanomaterials (GBNs) have emerged as versatile platforms for drug delivery, gene therapy, and photothermal therapy. These materials enable a synergistic approach, improving the efficacy of treatments while reducing side effects.
View Article and Find Full Text PDFCryogenic front-end circuit for capacitive sensing in superconducting gravimeters.
Rev Sci Instrum
January 2025
Capacitive sensors are commonly used in superconducting gravimeters due to their high resolution and low drift. This study developed a cryogenic front-end circuit for superconducting gravimeters to reduce the negative effects of parasitic capacitance on capacitive sensors. The front-end circuit comprises a noiseless superconducting transformer and a low-noise cryogenic preamplifier, both of which are positioned adjacent to the capacitive sensor probe.
View Article and Find Full Text PDFTransplant-Free Approach in Relapsed Hodgkin Lymphoma in Children, Adolescents, and Young Adults: A Nonrandomized Clinical Trial.
JAMA Oncol
January 2025
Children's Wisconsin, Milwaukee.
Importance: Retrieval strategies for children, adolescents, and young adults with relapsed classic Hodgkin lymphoma (cHL) aim to maintain efficacy while minimizing long-term toxic effects. Children, adolescents, and young adults with low-risk, relapsed cHL may benefit from replacing high-dose chemotherapy and autologous stem cell transplant with less intensive involved-site radiotherapy (ISRT).
Objective: To evaluate a risk-stratified, response-adapted, transplant-free approach for treatment of children, adolescents, and young adults with low-risk relapsed cHL with nivolumab plus brentuximab vedotin (BV) followed by BV plus bendamustine for patients with suboptimal response and ISRT (30.
Recombinant vs Egg-Based Quadrivalent Influenza Vaccination for Nursing Home Residents: A Cluster Randomized Trial.
JAMA Netw Open
January 2025
Transformative Health Systems Research to Improve Veteran Equity and Independence Center of Innovation, Veterans Affairs Providence Health Care System, Providence, Rhode Island.
Importance: Influenza vaccination remains the most important intervention to prevent influenza morbidity and mortality among nursing home residents. The additional effectiveness of recombinant influenza vaccine vs standard dose vaccines was demonstrated in outpatient older adults but has not been evaluated in nursing home populations.
Objective: To compare hospitalization rates among residents in nursing homes immunized with a recombinant vs a standard dose egg-based influenza vaccine.
This longitudinal study aimed to examine the long-term effects of Reminiscing and Emotion Training (RET), child maltreatment, and the COVID-19 pandemic on maternal elaboration and sensitive guidance during reminiscing. RET was developed to improve maternal elaborative and emotionally sensitive reminiscing among maltreating mothers of preschool-aged children. Of the original 248 mothers and their preschool-aged children who participated in the trial of RET, which included 165 families with maltreatment who were randomized to receive RET ( = 83) or a case management community standard condition (CS, = 82), and a group of demographically similar families with no history of child maltreatment, nonmaltreatment comparison (NC, = 83), 166 families participated in an assessment 5 years postintervention (Time 5; T5) at which children were aged 8-12 years.
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