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Dementia and Cognitive Impairment in an Urban Multiethnic Indigenous Community from Amazonas.
Dement Geriatr Cogn Dis Extra
December 2024
Department of Medical-Surgical Nursing, School of Nursing, University of São Paulo, São Paulo, Brazil.
Introduction: Studies about dementia in Indigenous communities are still scarce worldwide, especially in low-middle-income countries, limiting timely intervention in minority groups. Our research aimed to bridge this gap by determining the prevalence of dementia and mild cognitive impairment no dementia (CIND), and the associated factors, in a multiethnic Indigenous community in Manaus, Brazil.
Methods: A cross-sectional observational study evaluated the cognitive and functional performances of 141 Indigenous individuals (aged 50 and above).
Antibiotic Use and Subsequent Cognitive Decline and Dementia Risk in Healthy Older Adults.
Neurology
January 2025
From the Clinical and Translational Epidemiology Unit (Y.W., A.T.C.), and Division of Gastroenterology (Y.W., A.T.C.), Massachusetts General Hospital and Harvard Medical School, Boston; School of Public Health and Preventive Medicine (Z.Z., J.C.B., R.L.W., S.G.O., R.W., J.R.), Monash University, Melbourne; Menzies Institute for Medical Research (Z.Z.), University of Tasmania, Australia; Department of Pharmacy Practice and Science (E.J.E.. M.E.E.), College of Pharmacy, and Department of Family Medicine (M.E.E.), Carver College of Medicine, University of Iowa, Iowa City; Department of Immunology and Infectious Diseases (A.T.C.), Harvard T.H. Chan School of Public Health, Boston; and Cancer Center (A.T.C.), Massachusetts General Hospital, Boston, MA.
Background And Objectives: Antibiotics rapidly reduce intestinal bacterial diversity, leading to dysbiosis that persists for months to years. Although emerging evidence from retrospective and claims-based studies has linked dysbiosis to cognitive function, prospective data are lacking. We aim to examine the prospective association of antibiotics with cognitive aging among initially healthy older adults.
View Article and Find Full Text PDFLongitudinal Patterns and Predictors of Cognitive Impairment Classification Stability.
Arch Clin Neuropsychol
November 2024
Department of Psychology, University of Victoria, Cornett Building A236, 3800 Finnerty Road (Ring Rd), Victoria, BC, V8P 5C2, Canada.
Objective: Classifications such as Cognitive Impairment, No Dementia (CIND) are thought to represent the transitory, pre-clinical phase of dementia. However, increasing research demonstrates that CIND represents a nonlinear, unstable entity that does not always lead to imminent dementia. The present study utilizes a longitudinal repeated measures design to gain a thorough understanding of CIND classification stability patterns and identify predictors of future stability.
View Article and Find Full Text PDFCerebral perfusion and amyloidosis in the oldest-old.
Alzheimers Dement
December 2024
Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA.
Introduction: In a nested case-control study, we examined how cerebral perfusion relates to cognitive status and amyloid in the oldest-old (i.e., 90 years of age and older).
View Article and Find Full Text PDFSocioeconomic inequalities linked to the transitioning to neurocognitive disorders and mortality.
Sci Rep
November 2024
Department of Behavioural Science and Health, Institute of Epidemiology and Public Health, University College London, 1-19 Torrington Place, London, WC1E 7HB, UK.
Article Synopsis
- Research investigates the link between socioeconomic position (SEP) and the transition between cognitive states, including neurocognitive impairment and mortality risk.
- The study found significant differences in cognitive state transitions based on SEP, revealing that higher wealth is associated with a greater likelihood of improving cognitive function.
- Additionally, lower education levels correlate with increased mortality risk following dementia onset, suggesting that socioeconomic factors may influence both cognitive health and longevity.
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