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Female Brain and Endocrinological Research-Veteran (FemBER-Vet) study: A study protocol for identifying endocrinological, lifestyle and psychosocial determinants of brain health outcomes in female veterans for future intervention success.
PLoS One
January 2025
Female Brain & Endocrine Health Research (FemBER) Consortium.
Background: Recent studies have demonstrated a greater risk of dementia in female veterans compared to civilians; with the highest prevalence noted for former service women with a diagnosis of psychiatric (trauma, alcoholism, depression), and/or a physical health condition (brain injury, insomnia, diabetes). Such findings highlight the need for increased and early screening of medical and psychiatric conditions, and indeed dementia, in the female veteran population. Further, they call for a better understanding of the underlying biopsychosocial mechanisms that might confer heightened risk for female veterans, to tailor preventative and interventional strategies that support brain health across the lifespan.
View Article and Find Full Text PDFEffect of Dietary Ketosis and Nicotinamide Riboside on Hippocampal Krebs Cycle Intermediates and Mitochondrial Energetics in a DNA Repair-Deficient 3xTg/POLβ Alzheimer Disease Mouse Model.
J Neurochem
January 2025
The Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA.
Alzheimer disease is a neurodegenerative pathology-modifying mitochondrial metabolism with energy impairments where the effects of biological sex and DNA repair deficiencies are unclear. We investigated the therapeutic potential of dietary ketosis alone or with supplemental nicotinamide riboside (NR) on hippocampal intermediary metabolism and mitochondrial bioenergetics in older male and female wild-type (Wt) and 3xTgAD-DNA polymerase-β-deficient (3xTg/POLβ) (AD) mice. DNA polymerase-β is a key enzyme in DNA base excision repair (BER) of oxidative damage that may also contribute to mitochondrial DNA repair.
View Article and Find Full Text PDFFoods, dietary patterns, and risk of vascular dementia: a systematic review.
Nutr Metab (Lond)
December 2024
Human Nutrition and Exercise Research Centre, Centre for Healthier Lives, Population Health Sciences Institute, Newcastle University, Newcastle Upon Tyne, UK.
Background: Vascular dementia (VaD) is the second most common cause of dementia globally and is associated with a significant economic and social burden. Diet could represent an important tractable risk factor for VaD. We synthesised current evidence on associations between consumption of specific foods or dietary patterns and VaD risk.
View Article and Find Full Text PDFThe mechanism and related research progress of GLP-1 receptor agonists in treating Alzheimer's disease.
Yi Chuan
December 2024
Department of Endocrinology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Article Synopsis
- GLP-1 receptor agonists are primarily used for treating type 2 diabetes, but they show promise for other conditions like hypertension, liver disease, depression, and neurodegenerative diseases, particularly Alzheimer's.
- Research indicates that these drugs may have potential efficacy in Alzheimer's treatment, supported by animal models and some clinical studies.
- The article reviews recent advances in understanding how GLP-1 receptor agonists could work against Alzheimer's, focusing on the disease's mechanisms and their connection to diabetes.
Marchiafava-Bignami Disease: A Case Report of a Reversible Cause of Dementia.
Cureus
November 2024
Internal Medicine, Centro Hospitalar Universitário de Santo António, Porto, PRT.
Marchiafava-Bignami disease (MBD) is a rare neurological disorder predominantly associated with chronic alcohol use, characterized by demyelination and necrosis of the corpus callosum. The condition often presents with cognitive dysfunction, motor deficits, and altered consciousness, which can range from mild confusion to severe stupor. Early recognition and treatment are crucial for improving outcomes.
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