Pleomorphic adenoma of the base of the tongue is a rare tumour. A case of a 40-year-old female with pleomorphic adenoma of the tongue base is reported here, with a review of the literature. Complete excision of the mass was done transorally under general anaesthesia.
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http://dx.doi.org/10.1007/s12070-011-0136-7 | DOI Listing |
Carcinoma ex pleomorphic adenomas are rare malignant tumors of the salivary glands, primarily seen in older adults. They originate from benign pleomorphic adenomas, are aggressive, and have poorer prognosis. This case documents an unusual presentation of a massive carcinoma ex pleomorphic adenoma.
View Article and Find Full Text PDFVirchows Arch
January 2025
Department of Pathology, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic.
Pleomorphic adenoma (PA), the most prevalent salivary gland tumor, exhibits a diverse histological spectrum characterized by epithelial, myoepithelial, and mesenchymal patterns, and secretory products. However, a subset of PAs presents microscopic features suggestive of malignancy, leading to challenging and potentially significant diagnostic pitfalls. A comprehensive retrospective analysis was conducted on the Salivary Gland Tumor Registry, compiled by the authors.
View Article and Find Full Text PDFBMC Oral Health
January 2025
Department of Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.
Background: Aurora kinase A (AurkA) plays a vital role in mitosis and is therefore critical in tumors development and progression. There are a few studies on AurkA expression in salivary gland tumors. The aim of the present study was to evaluate the expression pattern of AurkA in the most common benign and malignant salivary gland tumors by immunohistochemistry.
View Article and Find Full Text PDFTransl Cancer Res
December 2024
Department of Stomatology, The First Hospital of Lanzhou University, Lanzhou, China.
Background: The rising incidence of parotid gland tumors, with a focus on pleomorphic adenomas (PMA) and Warthin tumors (WT), necessitates accurate preoperative distinction due to their treatment variability and PMA's malignant potential. Traditional imaging, while valuable, has limited accuracy. This study employs multi-slice computed tomography (MSCT) radiomics coupled with serum alpha-L-fucosidase (AFU) levels to develop a diagnostic model aimed at elevating clinical discernment and precision therapy delivery.
View Article and Find Full Text PDFGenes Chromosomes Cancer
January 2025
Sahlgrenska Center for Cancer Research, Department of Laboratory Medicine, University of Gothenburg, Gothenburg, Sweden.
Pleomorphic adenoma (PA) is the most common salivary gland tumor. PAs are characterized by chromosomal rearrangements of 8q12 and 12q14-15, leading to gene fusions involving the PLAG1 and HMGA2 oncogenes. Here, we performed the first comprehensive study of the transcriptomic and gene fusion landscape of 38 cytogenetically characterized PAs.
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