Unlabelled: Nonalcoholic steatohepatitis (NASH) is associated with obesity and type 2 diabetes, and an increased risk for liver cirrhosis and cancer. ELOVL family member 6, elongation of very long chain fatty acids (Elovl6), is a microsomal enzyme that regulates the elongation of C12-16 saturated and monounsaturated fatty acids (FAs). We have shown previously that Elovl6 is a major target for sterol regulatory element binding proteins in the liver and that it plays a critical role in the development of obesity-induced insulin resistance by modifying FA composition. To further investigate the role of Elovl6 in the development of NASH and its underlying mechanism, we used three independent mouse models with loss or gain of function of Elovl6, and human liver samples isolated from patients with NASH. Our results demonstrate that (1) Elovl6 is a critical modulator for atherogenic high-fat diet-induced inflammation, oxidative stress, and fibrosis in the liver; (2) Elovl6 expression is positively correlated with severity of hepatosteatosis and liver injury in NASH patients; and (3) deletion of Elovl6 reduces palmitate-induced activation of the NLR family pyrin domain-containing 3 inflammasome; this could be at least one of the underlying mechanisms by which Elovl6 modulates the progress of NASH.
Conclusion: Hepatic long-chain fatty acid composition is a novel determinant in NASH development, and Elovl6 could be a potential therapeutic target for the prevention and treatment of NASH.
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http://dx.doi.org/10.1002/hep.25932 | DOI Listing |
Life Sci
December 2024
College of Basic Medical Sciences, Shanxi Medical University, Taiyuan, China. Electronic address:
Front Nutr
November 2024
College of Animal Science and Technology, Northwest A&F University, Yangling, China.
Introduction: Fatty liver syndrome (FLS) is a prevalent nutritional and metabolic disease that mainly occurs in caged laying hens, causing substantial losses in the poultry industry. The study was carried out to explore the protective effect and potential mechanism of betaine on early FLS.
Methods: There were three groups: Con group (basal diet), FLS group (Dexamethasone injection + basal diet) and betaine group (Dexamethasone injection + basal diet with 8 g/kg betaine).
Int J Mol Sci
November 2024
Wuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, China.
Large-scale intensive feeding triggered reduced growth performance and nutritional value. Exogenous probiotics can promote the growth performance and nutritional value of fish through improving the intestinal microbiota. However, detailed research on the correlation between the intestinal microbiota, growth performance, and nutritional value remains to be elucidated.
View Article and Find Full Text PDFAnimals (Basel)
November 2024
Laboratory of Nutritional Physiology and Feeding, Department of Animal Science, Agricultural University of Athens, Iera Odos 75, GR-11855 Athens, Greece.
Int J Biol Macromol
December 2024
College of Marine Sciences, South China Agricultural University, Guangzhou 510642, China. Electronic address:
In mammals, elongation of very long-chain fatty acids protein 6 (ELOVL6) play a role in both the elongation of fatty acids and the development of associated inflammation. However, the function and transcriptional regulatory mechanisms of Elovl6 in invertebrates are poorly understood. This study aimed to examine the function of Elovl6 and its transcriptional regulatory mechanism in Scylla paramamosain.
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