Activation of NF-κB transcription factor is crucial for survival, proliferation, and differentiation of T cells. In this issue of Immunity, Paul et al. (2012) demonstrate that autophagy is a pathway by which TCR-activated NF-κB is turned over.
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alkyl quinolone response is dampened by .
mBio
December 2024
Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana, USA.
Unlabelled: The bacterium is an opportunistic pathogen that can cause lung, skin, wound, joint, urinary tract, and eye infections. While is known to exhibit a robust competitive response toward other bacterial species, this bacterium is frequently identified in polymicrobial infections where multiple species survive. For example, in prosthetic joint infections, can be identified along with other pathogenic bacteria including , , and .
View Article and Find Full Text PDFThe serotonergic psychedelic DOI impairs deviance detection in the auditory cortex.
J Neurophysiol
December 2024
Institute of Neuroscience, University of Oregon. Eugene, OR 97403.
Psychedelics are known to induce profound perceptual distortions, yet the neural mechanisms underlying these effects, particularly within the auditory system, remain poorly understood. In this study, we investigated the effects of the psychedelic compound 2,5-Dimethoxy-4-iodoamphetamine (DOI), a serotonin 2A receptor agonist, on the activity of neurons in the auditory cortex of awake mice. We examined whether DOI administration alters sound-frequency tuning, variability in neural responses, and deviance detection (a neural process reflecting the balance between top-down and bottom-up processing).
View Article and Find Full Text PDFParent-child relationship quality buffers the association between mothers' adverse childhood experiences and physiological synchrony.
J Child Psychol Psychiatry
December 2024
Department of Psychiatry, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Background: Family environment plays a critical role in shaping stress response systems. Concordance between mothers' and children's physiological states, specifically their Respiratory Sinus Arrhythmia (RSA), reflects dyadic co-regulation. Negative or weakened RSA synchrony during interactions is linked to various psychosocial risks, but existing research has focused on risks in the mother or child as opposed to the dyad.
View Article and Find Full Text PDFUrolithin A attenuates Doxorubicin-induced cardiotoxicity by enhancing PINK1-regulated mitophagy via Ambra1.
Chem Biol Interact
December 2024
Department of Cardiology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong,250021, People's Republic of China; Department of Cardiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, 250021, People's Republic of China; JiNan Key Laboratory of Cardiovascular Disease, Jinan, China. Electronic address:
Doxorubicin (Dox) is a widely used antineoplastics although its clinical usage is greatly limited by its cardiotoxicity. Several studies have depicted an essential role for dampened mitophagy and mitochondrial injury in Dox cardiotoxicity. However, preventative measure to alleviate Dox-evoked cardiotoxicity via targeting mitophagy and mitochondrial integrity remains elusive.
View Article and Find Full Text PDFThe role of FDI and energy intensity upon the consolidation of circular economies among the European Union.
J Environ Manage
December 2024
Hong Kong Metropolitan University, Lee Shau Kee School of Business and Administration, 30 Good Shepherd St, Ho Man Tin, Hong Kong.
This manuscript critically examines the intricate interplay between diverse foreign direct investment (FDI) flows, energy intensity, and their consequential effects on circular economies (CEs), specifically in terms of the waste recycling ratio, within the member states of the European Union over the period spanning from 2000 to 2021. Our findings substantiate that inflows and outflows of FDI have different implications for waste recycling, where an increase of 1% OFDI implies an increase of recycling ratio by 0.03%, a relationship that is potentially contingent upon the inherent characteristics of the flow itself in relation to its contributions to local productivity dynamics.
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