A population of nesfatin 1-like immunoreactive (LI) cells in the mucosal layer of the canine digestive tract.

Res Vet Sci

Department of Clinical Physiology, Faculty of Veterinary Medicine, University of Warmia and Mazury, 10-718 Olsztyn, Poland.

Published: December 2012

AI Article Synopsis

  • The study focused on analyzing nesfatin-1-like immunoreactive (LI) cells in the mucosal layer of dogs' digestive tracts for the first time.
  • It specifically examined the distribution of these cells in different parts of the digestive system and their relationship with other peptides like somatostatin (SOM) and vasoactive intestinal peptide (VIP).
  • The findings indicated varying numbers of nesfatin-1-LI cells across areas such as the gastric fundus and duodenum, but no co-localization with the other peptides was found, leaving the functions of these cells still unclear.

Article Abstract

The aim of this study was to investigate for the first time nesfatin-1-like immunoreactive (LI) cells in the mucosal layer of the canine digestive tract. Distribution of nesfatin-1 - LI cell bodies and the co-localization of nesfatin-1 with somatostatin (SOM), cocaine-and amphetamine-regulated transcript peptide (CART), protein gene product 9.5 (PGP 9.5) and vasoactive intestinal peptide (VIP) were studied by immunohistochemistry in the selected parts of the canine digestive tract. Evaluation of the nesfatin 1-LI cells number has been based on the counting of cell bodies per observation field. Nesfatin-1-LI cells amounted to 0.87±0.06, 1.06±0.02, 0.85±0.11 and 0.56±0.13 in gastric fundus, duodenum, jejunum and descending colon, respectively. The co-localization of nesfatin-1 with the other substances studied was not observed. Functions of nesfatin-1 - LI cells in the canine digestive tract are unknown.

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http://dx.doi.org/10.1016/j.rvsc.2012.06.002DOI Listing

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