AI Article Synopsis
- Cellular reprogramming allows adult cells to become induced pluripotent stem cells (iPSCs), creating patient-specific stem cells for studying diseases.
- Many iPSC lines have been developed from various disorders, enabling the differentiation of these cells into types that reflect disease characteristics.
- This technology offers a way to discover abnormal disease pathways and potential drugs, although there are still challenges in accurately modeling diseases and screening for treatments in the lab.
Article Abstract
Cellular reprogramming and generation of induced pluripotent stem cells (iPSCs) from adult cell types have enabled the creation of patient-specific stem cells for use in disease modeling. To date, many iPSC lines have been generated from a variety of disorders, which have then been differentiated into disease-relevant cell types. When a disease-specific phenotype is detectable in such differentiated cells, the reprogramming technology provides a new opportunity to identify aberrant disease-associated pathways and drugs that can block them. Here, we highlight recent progress as well as limitations in the use of iPSCs to recapitulate disease phenotypes and to screen for therapeutics in vitro.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3489983 | PMC |
| http://dx.doi.org/10.1016/j.gde.2012.05.005 | DOI Listing |
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