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Cardiac cells and mesenchymal stem cells derived extracellular vesicles: a potential therapeutic strategy for myocardial infarction.
Front Cardiovasc Med
December 2024
Department of Cardiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Despite improvements in clinical outcomes of acute myocardial infarction (AMI), mortality rates remain high, indicating the need for further understanding of the pathogenesis and developing more effective cardiac protection strategies. Extracellular vesicles (EVs) carry proteins and noncoding RNAs (ncRNAs) derived from different cardiac cell populations, mainly including cardiomyocytes, endothelial cells, endothelial progenitor cells, cardiac progenitor cells, cardiosphere-derived cells, immune cells, fibroblasts and cardiac telocytes have vital roles under both physiological and pathological process such as myocardial infarction (MI). The content of EVs can also indicate the status of their parental cells and serve as a biomarker for monitoring the risk of cardiac injury.
View Article and Find Full Text PDFEight-Year Outcomes of Cardiosphere-Derived Cells in Single Ventricle Congenital Heart Disease.
J Am Heart Assoc
November 2024
Department of Regenerative Medicine, Center for Innovative Clinical Medicine Okayama University Hospital Okayama Japan.
Article Synopsis
- A study was conducted to evaluate the long-term effects of Cardiosphere-derived cell (CDC) infusion in patients with single ventricle heart disease, focusing on outcomes over an 8-year period.
- Among 93 patients, those who received CDC infusion experienced a statistically significant reduction in late failure and adverse events compared to control patients, although overall survival rates at 8 years did not significantly differ.
- The beneficial effects of CDC treatment on survival became more apparent by the 4-year mark, particularly for patients with heart failure, suggesting that CDC infusion may provide sustained clinical advantages over time.
Deconstructing Regenerative Medicine: From Mechanistic Studies of Cell Therapy to Novel Bioinspired RNA Drugs.
Circ Res
September 2024
Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA.
All Food and Drug Administration-approved noncoding RNA (ncRNA) drugs (n≈20) target known disease-causing molecular pathways by mechanisms such as antisense. In a fortuitous evolution of work on regenerative medicine, my coworkers and I inverted the RNA drug discovery process: first we identified natural disease-modifying ncRNAs, then used them as templates for new synthetic RNA drugs. Mechanism was probed only after bioactivity had been demonstrated.
View Article and Find Full Text PDFSurface engineering enhances the therapeutic potential of systemically delivered extracellular vesicles following acute myocardial infarction.
FASEB J
September 2024
Department of Medicine, Division of Cardiology, Jacobs School of Medicine and Biomedical Sciences, Buffalo, New York, USA.
The objective of the study was to assess the therapeutic efficacy of targeting remote zone cardiomyocytes with cardiosphere-derived cell (CDC) extracellular vesicles (EVs) delivered via intramyocardial and intravenous routes following acute myocardial infarction (MI). Cardiomyocyte (CM) cell death plays a significant role in left ventricular (LV) remodeling and cardiac dysfunction following MI. While EVs secreted by CDCs have shown efficacy in promoting cardiac repair in preclinical models of MI, their translational potential is limited by their biodistribution and requirement for intramyocardial delivery.
View Article and Find Full Text PDFRegulation mechanism of microRNAs in cardiac cells-derived exosomes in cell crosstalk.
Front Pharmacol
August 2024
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China.
The heart is a multicellular system, and the intercellular crosstalk mechanism is very important for the growth and development of the heart and even the organs, tissues, and cells at a distance. As a kind of extracellular vesicle, exosomes are released by different types of cells and can carry specific genetic material, endosomal proteins, cytokines, etc., which are the main material basis for mediating cell crosstalk mechanism.
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