Spiny keratoderma is an infrequent dermatosis consisting of multiple projections located on the palms and soles, with the distinct histopathology feature of a parakeratotic column above a hypogranular epidermis. This entity has been reported under several different names, such as punctate porokeratotic keratoderma, punctate keratoderma, palmar filiform hyperkeratosis, and spiny keratoderma of the palms and soles. Most of the cases described are acquired, although there are also familial cases. Since this disease has been under-diagnosed and under-reported, it is important for dermatologists to keep spiny keratoderma of the palms and soles in mind. We present a familial case of spiny keratoderma and review the literature.

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A 14-year-old male with disseminated superficial porokeratosis and a family history of the same lesions on his maternal side presented with spiny keratoderma. Spiny keratoderma is a dermatosis characterized by multiple punctate keratotic neoformations on the palms and soles. It is considered a rare disease, with fewer than 84 cases reported in the world medical literature to date.

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  • * Histological analysis shows these lesions are made up of distinct columns of abnormal keratin on a thin outer skin layer, and sporadic cases may be linked to chronic illnesses or cancers.
  • * A case study describes an elderly man with liver cirrhosis and cancer who experienced a remission of skin lesions two months after a liver transplant, suggesting the condition may relate to his cancer diagnosis.
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  • - Spiny keratoderma is a rare skin condition characterized by small, spiny growths on the palms and soles, which can be inherited or acquired.
  • - The acquired form may be linked to other health issues but not necessarily to cancer, and it can be confused with similar skin conditions like arsenical keratosis.
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