AI Article Synopsis
- Hemidesmus indicus (HI) is traditionally used in Indian herbal medicine for liver and kidney issues, and this study looks at its protective effects against damage caused by bromobenzene in rat kidneys.
- Rats treated with bromobenzene showed significant mitochondrial dysfunction, oxidative stress, and kidney damage, whereas prior treatment with HI extract greatly mitigated these harmful effects.
- The protective benefits of HI were found to be more effective than those provided by vitamin E, suggesting its stronger antioxidant properties.
Article Abstract
Hemidesmus indicus (HI) is used in ancient Indian traditional herbal medicine to treat hepatic and renal disorders. The present study was designed to investigate the protective effect of HI aqueous extract against bromobenzene induced mitochondrial dysfunction in rat kidneys. Rats were administered bromobenzene with or without prior administration of HI or vitamin E. At the end of the experiment animals were sacrificed and kidneys were obtained to study mitochondrial function, oxidative stress parameters and histopathology. Administration of bromobenzene caused significant changes like: decrease in the mitochondrial respiration and P/O ratios, increase in lipid peroxidation and protein oxidation, and decrease in the activities of antioxidant enzymes (catalase, glutathione reductase, glutathione peroxidase and superoxide dismutase) in mitochondria with significant histopathological changes in the kidney. Prior administration of HI extract showed a significant protection against bromobenzene induced changes in the kidney and this effect is attributed to the antioxidant and free radical scavenging potential of the HI. The protection was much better with HI compared to vitamin E.
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| http://dx.doi.org/10.1142/S0192415X12500437 | DOI Listing |
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