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Prilling as an Effective Tool for Manufacturing Submicrometric and Nanometric PLGA Particles for Controlled Drug Delivery to Wounds: Stability and Curcumin Release.
Pharmaceutics
January 2025
Department of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, 84084 Fisciano, Italy.
Background/objectives: This study investigates for the first time the use of the prilling technique in combination with solvent evaporation to produce nano- and submicrometric PLGA particles to deliver properly an active pharmaceutical ingredient. Curcumin (CCM), a hydrophobic compound classified under BCS (Biopharmaceutics Classification System) class IV, was selected as the model drug.
Methods: Key process parameters, including polymer concentration, solvent type, nozzle size, and surfactant levels, were optimized to obtain stable particles with a narrow size distribution determined by DLS analysis.
Zebrafish: A Cost-Effective Model for Enhanced Forensic Toxicology Capabilities in Low- and Middle-Income Countries.
Cureus
December 2024
Zebrafish Research Unit, Mahatma Gandhi Medical Advanced Research Institute, Sri Balaji Vidyapeeth (Deemed-to-be-University), Pondicherry, IND.
Low- and middle-income countries (LMICs) are increasingly challenged by the rising burden of medicolegal cases. Traditional forensic infrastructure and in vivo rodent models often have significant limitations due to high costs and ethical concerns. As a result, zebrafish () are gaining popularity as an attractive alternative model for LMICs because of their cost-effectiveness and practical advantages.
View Article and Find Full Text PDFAccelerating computational fluid dynamics simulation of post-combustion carbon capture modeling with MeshGraphNets.
Front Artif Intell
January 2025
Lawrence Livermore National Laboratory, Livermore, CA, United States.
Packed columns are commonly used in post-combustion processes to capture CO emissions by providing enhanced contact area between a CO-laden gas and CO-absorbing solvent. To study and optimize solvent-based post-combustion carbon capture systems (CCSs), computational fluid dynamics (CFD) can be used to model the liquid-gas countercurrent flow hydrodynamics in these columns and derive key determinants of CO-capture efficiency. However, the large design space of these systems hinders the application of CFD for design optimization due to its high computational cost.
View Article and Find Full Text PDFIn Situ Raman Spectroscopy-Enabled Microfluidic Gel Chromatography for Revealing Real-Time Separation Dynamics of Single-Walled Carbon Nanotubes.
Polymers (Basel)
January 2025
Department of Materials Science and Engineering, Gachon University, Seongnam 13120, Republic of Korea.
Single-walled carbon nanotubes (SWNTs) exhibit distinct electronic properties, categorized as metallic or semiconducting, determined by their chirality. The precise and selective separation of these electronic types is pivotal for advancing nanotechnology applications. While conventional gel chromatography has been widely employed for large-scale separations, its limitations in addressing microscale dynamics and electronic-type differentiation have persisted.
View Article and Find Full Text PDFOn-Demand Selection of the Latent Domain Orientation in Spray-Deposited Block Copolymer Thin Films.
ACS Nano
January 2025
Center for Functional Nanomaterials, Brookhaven National Laboratory, Upton, New York 11973, United States.
With their ability to self-assemble spontaneously into well-defined nanoscale morphologies, block copolymer (BCP) thin films are a versatile platform to fabricate functional nanomaterials. An important challenge to wider deployment of BCPs in nanofabrication is combining precise control over the nanoscale domain orientation in BCP assemblies with scalable deposition techniques that are applicable to large-area, curved, and flexible substrates. Here, we show that spray-deposited smooth films of a nominally disordered BCP exhibit latent orientations, which can be prescriptively selected by controlling solvent evaporation during spray casting.
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