The Linear Non-Threshold (LNT) process is used by virtually all governmental agencies to compute incidence of cancer as a consequence of exposure to a carcinogen. This comment applies the concept of Best Available Science (BAS) Metrics for Evaluation of Scientific Claims (MESC) derived from BAS to issues related to reliability of LNT hypothesis. This paper identifies the level of maturity of the LNT hypothesis and the associated uncertainties.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375493 | PMC |
| http://dx.doi.org/10.2203/dose-response.11-019.Moghissi | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
An examination of the dose rate effect in mice assuming that the carcinogenic effect of radiation is life shortening resulting from a tissue reaction.
Int J Radiat Biol
January 2025
Department of Radiation Biosciences, Radiation Effects Research Foundation, Hiroshima, Japan.
Purpose: Radiation exposures do not seem to increase the proportion of mice dying from tumors, but rather cause a shift in the appearance of spontaneous cancers, allowing them to appear earlier, and hence produce a life shortening effect. Then, it was possible to estimate the effect of the dose rate on the carcinogenic effects of radiation using life shortening effects as a measure.
Conclusion: The dose response for the induction of life shortening was linear under acute exposure conditions, which indicates that the response under chronic exposure conditions is also likely to be linear, and hence the dose rate factor (DRF) would be constant throughout the dose.
Cancer risk associated with low-dose ionizing radiation: A systematic review of epidemiological and biological evidence.
Mutat Res Rev Mutat Res
December 2024
Department of Radiology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China. Electronic address:
Article Synopsis
- The current radiation protection standards for cancer risk, primarily based on the Life Span Study (LSS), lack sufficient supporting evidence for low-dose ionizing radiation (LDIR) effects.
- There is a growing need for substantial evidence and potential thresholds for cancer risk, especially with increased medical radiation use, prompting a review of epidemiological studies.
- Recent advances in understanding the biology of LDIR-induced cancer suggest that factors like DNA damage, chromosome changes, and stem cell behavior may challenge existing risk models, indicating new areas for future research.
Improving the construction and prediction strategy of the Air Quality Health Index (AQHI) using machine learning: A case study in Guangzhou, China.
Ecotoxicol Environ Saf
November 2024
Department of Preventive Medicine, School of Public Health, Guangzhou Medical University, Xinzao, Panyu District, Guangzhou 511436, China; Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. Electronic address:
Effectively capturing the risk of air pollution and informing residents is vital to public health. The widely used Air Quality Index (AQI) has been criticized for failing to accurately represent the non-threshold linear relationship between air pollution and health outcomes. Although the Air Quality Health Index (AQHI) was developed to address these limitations, it lacks comprehensive construction criteria.
View Article and Find Full Text PDFMuller letter reveals scientific scandal that discredits evidence used to support LNT.
Chem Biol Interact
October 2023
Departments of Neurology and Biochemistry, Pellegrino Center for Clinical Bioethics, Georgetown University Medical Center, Washington, DC, 20007, USA. Electronic address:
A newly discovered letter written by Hermann J. Muller in August 1948, reveals that he claimed to have evidence that multiple papers by Frederick Hanson and Florence Heys, including those that supported the linear non-threshold (LNT) dose response model for hereditary and cancer risk assessment, were fraudulent and thus untrustworthy. Muller failed to bring this issue, which he referred to as a major scientific scandal, to the attention of the scientific community, remaining silent for the remainder of his career.
View Article and Find Full Text PDFShort-term ozone exposure and cancer mortality in Brazil: A nationwide case-crossover study.
Int J Cancer
November 2024
Climate Air Quality Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia.
Exposure to ambient ozone (O) is linked to increased mortality risks from various diseases, but epidemiological investigations delving into its potential implications for cancer mortality are limited. We aimed to examine the association between short-term O exposure and site-specific cancer mortality and investigate vulnerable subgroups in Brazil. In total 3,459,826 cancer death records from 5570 Brazilian municipalities between 2000 and 2019, were included.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!