Testing standards are more fundamental from a metrological perspective and less controversial from an industrial perspective than product standards, representing a path of less resistance towards the standardization and commercialization of lab on a chip technology. In this Focus article, the development of a lab on a chip testing standard is considered in the context of autofluorescence. This material property of microfluidic and nanofluidic devices is of increasing importance due to the growing interest in sensitive fluorescence measurements performed in chips fabricated from plastics.
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http://dx.doi.org/10.1039/c2lc40511c | DOI Listing |
Sci Adv
January 2025
QTF Centre of Excellence, Department of Electronics and Nanoengineering, Aalto University, Espoo FI-00076 Aalto, Finland.
Reconstructive optoelectronic spectroscopy has generated substantial interest in the miniaturization of traditional spectroscopic tools, such as spectrometers. However, most state-of-the-art demonstrations face fundamental limits of rank deficiency in the photoresponse matrix. In this work, we demonstrate a miniaturized spectral sensing system using an electrically tunable compact optoelectronic interface, which generates distinguishable photoresponses from various input spectra, enabling accurate spectral identification with a device footprint of 5 micrometers by 5 micrometers.
View Article and Find Full Text PDFLab Chip
January 2025
State Key Laboratory of Fine Chemicals, Department of Pharmaceutical Engineering, School of Chemical Engineering, Dalian University of Technology, #2 Linggong Road, Dalian, 116024, China.
Organoids-on-a-chip exhibit significant potential for advancing disease modeling, drug screening, and precision medicine, largely due to their capacity to facilitate interactions among organoids. However, the influence of chip design on these interactions remains poorly understood, primarily due to our limited knowledge of the mediators of communication and the complexity of interaction dynamics. This study demonstrates that analyzing albumin secretion from liver organoids within an organoids-on-a-chip system can provide a measure of the interaction intensity among organoids, offering valuable insights into how chip design influences these interactions.
View Article and Find Full Text PDFUltrasonics
January 2025
Acoustic and Application Group, Federal University of Alagoas, Campus Arapiraca, Brazil. Electronic address:
3D printing technology, also known as Additive Manufacturing (AM), has revolutionized object prototyping, offering a simple, cost-effective, and efficient approach to creating structures with diverse spatial features. However, the mechanical properties of 3D-printed structures are highly dependent on the material type and manufacturing technique employed. In this study, ultrasonic testing methods were used to comprehensively characterize standard samples produced using two popular printing techniques: material extrusion and vat photopolymerization.
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January 2025
VERAXA Biotech GmbH, 69124 Heidelberg, Germany.
Microfluidic droplet sorting has emerged as a powerful technique for a broad spectrum of biomedical applications ranging from single cell analysis to high-throughput drug screening, biomarker detection and tissue engineering. However, the controlled and reliable retrieval of selected droplets for further off-chip analysis and processing is a significant challenge in droplet sorting, particularly in high-throughput applications with low expected hit rates. In this study, we present a microfluidic platform capable of sorting and dispensing individual droplets with minimal loss rates.
View Article and Find Full Text PDFSci Rep
January 2025
U1248 Pharmacology & Transplantation, Inserm, Univ. Limoges, Limoges, France.
Deciphering the sources of variability in drug responses requires to understand the processes modulating drug pharmacokinetics. However, pharmacological research suffers from poor reproducibility across clinical, animal, and experimental models. Predictivity can be improved by using Organs-on-Chips, which are more physiological, human-oriented, micro-engineered devices that include microfluidics.
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