AI Article Synopsis
- The Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition was used to create a new compound that inhibits HGF-induced cell scattering in MDCK epithelial cells.
- The compound also showed effectiveness in preventing tumorigenesis in H1437 non-small-cell lung cancer and GTL-16 human gastric carcinoma cells.
- Docking studies indicate that the binding mode of this new compound in the ATP binding site of Met is similar to that of the previously reported active compound Triflorcas.
Article Abstract
The use of Cu(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition permitted the synthesis of a new compound that is able to inhibit the HGF-induced scattering of MDCK (epithelial cells) and in vitro tumorigenesis of H1437 (non-small-cell lung cancer) and GTL-16 (human gastric carcinoma). In agreement with biochemical and biological results, docking studies within the ATP binding site of Met suggested for the new synthesized compound a binding mode similar to that of the active compound Triflorcas previously reported.
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| http://dx.doi.org/10.1016/j.bmcl.2012.05.078 | DOI Listing |
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