Immune surveillance of pre-cancerous senescent hepatocytes limits hepatocellular carcinoma development.

Oncoimmunology

Helmholtz Centre for Infection Research; Braunschweig, Germany ; Hannover Medical School; Department of Gastroenterology, Hepatology and Endocrinology; Hannover, Germany.

Published: May 2012

Here we discuss a recently published study from our group on how a continuous CD4 T-cell dependent immune clearance of premalignant senescent cells, designated "senescence surveillance," restricts liver cancer development.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382854PMC
http://dx.doi.org/10.4161/onci.19128DOI Listing

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