Purpose: To determine the incidence and contribution of different types of glaucoma to blindness at Irrua Specialist Teaching Hospital, a suburban tertiary care hospital in Edo State, Nigeria.
Methods: Medical records of all new patients with glaucoma who presented to the eye clinic of the hospital from June 2007 to May 2009 were reviewed.
Results: Out of a total of 2,742 new patients seen over the study period, 177 (6.5%) subjects had glaucoma which included primary open angle glaucoma (130 cases, 73.4%), juvenile glaucoma (31 patients, 17.5%), secondary glaucoma (10 subjects, 5.6%), congenital glaucoma (3 cases, 1.7%) and primary angle closure glaucoma (3 persons, 1.7%). Of patients with primary open angle glaucoma, 23 (17.7%) were blind based on visual acuity criteria and 67 (51.5%) were blind based on visual field criteria.
Conclusion: Glaucoma remains a blinding scourge; late presentation, especially in rural areas, is an important factor predisposing to blindness. In this Nigerian population primary open angle glaucoma was the most prevalent subtype of the disease but primary angle closure glaucoma was rare.
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PLoS One
January 2025
Biomedical Sciences Research Institute, Centre for Genomic Medicine, Ulster University, Coleraine, Northern Ireland, United Kingdom.
Pseudoexfoliation glaucoma is a severe form of secondary open angle glaucoma and is associated with activation of the TGF-β pathway by TGF-β1. MicroRNAs (miRNAs) are small non-coding RNA species that are involved in regulation of mRNA expression and translation. To investigate what glaucomatous changes occur in the trabecular meshwork and how these changes may be regulated by miRNAs, we performed a bioinformatics analysis resulting in a miRNA-mRNA interactome.
View Article and Find Full Text PDFPLoS One
January 2025
Faculty of Medicine and Health Technology, Department of Ophthalmology, Tampere University, Tampere, Finland.
Background: The long-term patterns in first-line glaucoma medication are not well established. Exploring these in longitudinal and population-based settings would provide information for the healthcare systems to plan glaucoma care accordingly.
Objective: To evaluate patterns in first-line glaucoma monotherapy in Finland during 1995-2019 based on nationwide survey and register data.
Front Med (Lausanne)
January 2025
Eye Center of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Introduction: Glaucoma, a leading cause of irreversible blindness, is characterized by optic neuropathy and retinopathy, with primary open-angle glaucoma (POAG) being the most prevalent form. The primary pathogenic mechanism of POAG involves elevated intraocular pressure caused by chronic fibrosis of the trabecular meshwork (TM). Autophagy, a critical process for maintaining cellular homeostasis, has been implicated in fibrosis across various organs.
View Article and Find Full Text PDFCureus
January 2025
Ophthalmology, Royal Free Hospital, London, GBR.
Endoscopic cyclophotocoagulation (ECP) offers a viable alternative for managing advanced primary open-angle glaucoma (POAG) in patients at risk of ocular hypotony. We describe a case of a successful outcome with ECP in a patient who developed ocular hypotony secondary to Preserflo surgery. A 93-year-old South Asian male experienced significant visual field deterioration and ocular hypotony following Preserflo surgery on the left eye, complicated by a severe cough from COVID-19.
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