AI Article Synopsis
- Organophosphate poisoning, specifically from chlorpyrifos, can lead to delayed neurological issues, including a rare form of pure motor neuropathy without sensory loss.
- A case study of a 15-year-old girl demonstrated cholinergic crisis after ingesting chlorpyrifos, with subsequent development of neurological symptoms like motor neuron signs and urinary incontinence weeks later.
- The study suggests that chronic neurotoxicity from OPs depends on multiple factors, and the resulting damage primarily affects motor functions, potentially leading to severe complications like myelopathy.
Article Abstract
Introduction: Organophosphate (OP) poisoning is known to cause delayed neurological manifestations. Chlorpyrifos, an OP, causes a delayed syndrome that is characterized by a motor sensory polyneuropathy. Pure motor neuropathy with intact sensory conduction is rarely documented. Rapidly evolving delayed myelopathy is extremely uncommon.
Case Report: A healthy 15-year-old female was admitted to hospital with cholinergic crisis due to ingestion of a large dose of chlorpyrifos (OP). She was treated with atropine and recovered completely without any neurological symptoms or signs. She came to hospital 6 weeks later with upper and lower motor neuron signs involving the lower limbs without sensory loss. By the end of 7 weeks, there was urinary incontinence. At 2-month follow-up, she had progressive spasticity. Electrophysiological studies revealed a pure motor neuropathy. Spine magnetic resonance imaging showed early signs of thoracic cord atrophy. Other causes of myelopathy were excluded.
Conclusions: Chronic neurotoxicity due to OP poisoning is dependent on several factors: chemical composition of the OP, dose systematized, and the administration of anitcholinergics for cholinergic crisis. The pathology of OP-induced delayed neuropathy involves a central-peripheral distal axonopathy. Peripheral distal axonopathy results in a predominantly motor polyneuropathy. Axonopathy of the central nervous system results in myelopathic features that makes for a poorer prognosis.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/NRL.0b013e318261035b | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Hypercapnic warm-up and re-warm-up-A novel experimental approach in swimming sprint.
PLoS One
January 2025
Department of Physiology and Biochemistry, Faculty of Physical Education and Sport Science, Wroclaw University of Health and Sport Sciences, Wroclaw, Poland.
The purpose of this study was to determine the effective warm-up protocol using an added respiratory dead space (ARDS) 1200 ml volume mask to determine hypercapnic conditions, on the swimming velocity of the 50 m time trial front crawl. Eight male members of the university swimming team, aged 19-25, performed three different warm-up protocols: 1) standardized warm-up in water (WUCON); 2) hypercapnic warm-up in water (WUARDS); 3) hypercapnic a 20-minute transition phase on land, between warm-up in water and swimming test (RE-WUARDS). The three warm-up protocols were implemented in random order every 7th day.
View Article and Find Full Text PDFImproving Electrical Conductivity of Commercially Pure Aluminium: The Synergistic Effect of AlB8 Master Alloy and Heat Treatment.
Materials (Basel)
January 2025
Department of Mechanical Engineering, Ege University, Izmir 35040, Turkey.
This study aims to enhance the electrical conductivity of commercially pure aluminium by minimizing impurities and grain boundaries in its microstructure, ultimately improving the efficiency of electric motors constructed from rotors with squirrel cages made from this material. For this purpose, an aluminium-boron (AlB8) master alloy was added to aluminium with a purity of 99.7%, followed by the application of a grain-coarsening heat treatment to the rotors.
View Article and Find Full Text PDFEarly Motor Signs in Pathologically Verified Alzheimer's Disease and Lewy Body Disease.
Mov Disord Clin Pract
January 2025
Department of Neurology, Keck School of Medicine at the University of Southern California, Los Angeles, California, USA.
Background: The neuropathologies of Alzheimer's disease (AD) and Lewy body disease (LBD) commonly co-occur. Parkinsonism is the hallmark feature in LBD but it can be difficult to predict the presence of these co-pathologies early in the course of clinical disease. Timely diagnosis has crucial implications, especially with the advent of disease-modifying therapies.
View Article and Find Full Text PDFElectrophysiological Abnormalities in Finger Extension Weakness and DOwnbeat Nystagmus Motor Neuron Disease: Three New Patients and Review of the Literature.
Muscle Nerve
January 2025
Service ENMG et de Pathologies Neuromusculaires, Centre de référence Des Maladies Neuromusculaires PACA-Réunion-Rhône Alpes, Hôpital Neurologique Pierre Wertheimer, Hospices Civils de Lyon, Bron, France.
Introduction/aims: Finger Extension Weakness and DOwnbeat Nystagmus Motor Neuron Disease (FEWDON-MND) is characterized by motor weakness predominantly affecting finger extension, accompanied by downbeat nystagmus. To date, only 11 patients have been reported. The present study adds a further three and aims to provide a more detailed description of the electrodiagnostic features of these patients.
View Article and Find Full Text PDFIdentifying impairments and compensatory strategies for temporal gait asymmetry in post-stroke persons.
Sci Rep
January 2025
Neurorehabilitation Research Center, Kio University, 4-2-2 Umaminaka, Kitakatsuragi-gun, Koryo, Nara, 635-0832, Japan.
In post-stroke persons, temporal gait asymmetry (TGA) during comfortable gait involves a combination of pure impairments and compensatory strategies. In this study, we aimed to differentiate between pure impairments and compensatory strategies underlying TGA in post-stroke individuals and identify associated clinical factors. We examined 39 post-stroke individuals who participated in comfortable walking speed (CWS) and rhythmic auditory cueing (RAC).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!