Wound dressings are used during patient radiotherapy treatments, particularly in cases of radiation induced lesions. Potentially, the presence of a dressing may increase the dose to the skin, further aggravating the skin reaction and decrease the dose at depth. The changes are dependent on linear accelerator beam type and beam quality and were determined for 4 and 10 MV photon energies and 6 and 15 MeV electron energies using a slab phantom and fixed separation parallel plate chambers. Since these dressings have been designed to be used on exuding wounds, measurements were taken under eight different wound dressings in both dry and wet state. Irradiations with photon energies increased the skin dose significantly (max. increase: 68.1 %; average increase: 48 %) with little or no change to dose at depth. Electron beam energies showed little or no change to doses at the surface, but the dose distribution was shifted towards the surface. The maximum decrease in dose at depth was 3.6 % for 6 and 15 MeV through all dressings except one and was therefore considered to be clinically insignificant. A change in dose at surface of 9.7 % and at R(50) of 25.9 %, equivalent to a shift of dose towards the surface of 7.5 mm, was measured for one dressing. This demonstrates that it is possible for a wet dressing to significantly alter electron beam dosimetry.
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Gut Pathog
January 2025
Diarrheal Pathogens Research Unit (DPRU), Department of Virology, Sefako Makgatho Health Sciences University, Ga-rankuwa, Pretoria, South Africa.
Bacterial flagellin, a potent intestinal innate immune activator, prevents murine rotavirus (RV) infection independent of adaptive immunity and interferons. The flagellin-induced immunity is mediated by Toll-like receptor (TLR5) and Nod-like receptor C4 (NLRC4), which elicit the production of interleukins 22 (IL-22) and IL-18, respectively. Here, we assessed whether a high abundance of flagellin at the time of vaccination would negatively affect the oral RV vaccine take.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Food Toxicology and Contaminant, National Research Centre, Dokki, Giza, Egypt.
This study evaluates the potential of ozonated corn starch (OCS) and ultrasonicated ozonated corn starch (USOCS) as adsorbents for patulin removal in buffer solutions. The results indicated that dual modification significantly altered the starch's structure, introducing functional groups such as carbonyl and carboxyl groups, and increasing its surface area. These modifications led to enhanced patulin adsorption capacity.
View Article and Find Full Text PDFJ Immunother Cancer
January 2025
Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Purpose: BMS-986299 is a first-in-class, NOD-, LRR-, and pyrin-domain containing-3 (NLRP3) inflammasome agonist enhancing adaptive immune and T-cell memory responses.
Materials And Methods: This was a phase-I (NCT03444753) study that assessed the safety and tolerability of intra-tumoral BMS-986299 monotherapy (part 1A) and in combination (part 1B) with nivolumab, and ipilimumab in advanced solid tumors. Reported here are single-center results.
Colloids Surf B Biointerfaces
January 2025
Department of Neurosurgery, The Affiliated Ganzhou Hospital, Jiangxi Medical College, Nanchang University, Ganzhou 341000, China. Electronic address:
To address the medical challenges posed by glioblastoma, a novel and high-performance tumor inhibitor (La@FA-CDs) composed of folic acid and lanthanum nitrate hexahydrate, was successfully synthesized and demonstrated effectiveness in inhibiting the growth of U251 and LN299 cells. The microstructure of La@FA-CDs was extensively analyzed by FTIR, UV-Vis, XPS, TEM, AFM NMR, and nanoparticle size analyzer. The optical and electrical properties of La@FA-CDs were characterized using a fluorescence spectrometer and a zeta potential analyzer.
View Article and Find Full Text PDFPhys Med Biol
January 2025
Joint Department of Physics, The Institute of Cancer Research and The Royal Marsden NHS Foundation Trust, Downs Road, Sutton, London, Surrey, SM2 5PT, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND.
This study aims to develop and evaluate a fast and robust deep learningbased auto-segmentation approach for organs at risk in MRI-guided radiotherapy of pancreatic cancer to overcome the problems of time-intensive manual contouring in online adaptive workflows. The research focuses on implementing novel data augmentation techniques to address the challenges posed by limited datasets. Approach: This study was conducted in two phases.
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