AI Article Synopsis
- RNA interference (RNAi) pathways play a crucial role in various biological functions like gene regulation and antiviral defenses in eukaryotes.
- Despite being conserved across different species, there are significant differences in RNAi mechanisms among plants, invertebrates, and mammals.
- Recent studies suggest that penaeid shrimp have functional RNAi machinery, but the role of RNAi in their immune responses to viruses is still not well understood.
Article Abstract
Over the last decade, RNA interference pathways have emerged in eukaryotes as critical regulators of many diverse biological functions including, among others, transcriptional gene regulation, post-transcriptional gene silencing, heterochromatin remodelling, suppression of transposon activity, and antiviral defences. Although this gene silencing process has been reported to be relatively well conserved in species of different phyla, there are important discrepancies between plants, invertebrates and mammals. In penaeid shrimp, the existence of an intact and functional RNAi machinery is supported by a rapidly growing body of evidence. However, the extent to which this process participates to the host immune responses remains poorly defined in this non-model organism. This review summarizes our current knowledge of RNAi mechanisms in shrimp and focuses on their implication in antiviral activities and shrimp immune defences.
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