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Utility of a C-Spirulina Stable Isotope Gastric Emptying Breath Test in Diabetes Mellitus.
Neurogastroenterol Motil
January 2025
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Background: The carbon-13 spirulina gastric emptying breath test (GEBT) is approved to identify delayed, but not accelerated, gastric emptying (GE). We compared the utility of the GEBT to scintigraphy for diagnosing abnormal GE in patients with diabetes mellitus.
Methods: Twenty-eight patients with diabetes ate a 230-kcal test meal labeled with technetium 99 m and C-spirulina, after which 10 scintigraphic images and breath samples (baseline, 15, 30, 45, 60, 90, 120, 150, 180, 210, and 240 min) were collected on 2 occasions 1 week apart.
Cytokinin negatively regulates tomato fruit ripening by influencing the ethylene pathway.
Plant Cell Rep
January 2025
College of Life Sciences, Nanjing Agricultural University, Nanjing, 210095, China.
Reducing endogenous CK levels accelerates fruit ripening in tomato by regulating ethylene biosynthesis and signalling pathway. Tomato is a typical climacteric fruit and is recognized as one of the most important horticultural crops globally. The ripening of tomato fruits is a complex process, highly regulated by phytohormones.
View Article and Find Full Text PDFAccelerated Endosomal Escape of Splice-Switching Oligonucleotides Enables Efficient Hepatic Splice Correction.
ACS Appl Mater Interfaces
January 2025
Faculty of Life Sciences, Department of Pharmaceutical Sciences, Laboratory of Macromolecular Cancer Therapeutics (MMCT), University of Vienna, Josef-Holaubek-Platz 2, 1090 Vienna, Austria.
Splice-switching oligonucleotides (SSOs) can restore protein functionality in pathologies and are promising tools for manipulating the RNA-splicing machinery. Delivery vectors can considerably improve SSO functionality in vivo and allow dose reduction, thereby addressing the challenges of RNA-targeted therapeutics. Here, we report a biocompatible SSO nanocarrier, based on redox-responsive disulfide cross-linked low-molecular-weight linear polyethylenimine (cLPEI), for overcoming multiple biological barriers from subcellular compartments to en-route serum stability and finally in vivo delivery challenges.
View Article and Find Full Text PDFKat7 accelerates osteoarthritis disease progression through the TLR4/NF-κB signaling pathway.
J Mol Med (Berl)
January 2025
Department of Orthopedics, The First Affiliated Hospital of Weifang Medical University (Weifang People's Hospital), Weifang, 261000, China.
Osteoarthritis (OA) is a common degenerative bone and joint disease with an unclear pathogenesis. Our study identified that the histone acetyltransferase encoded by Kat7 is upregulated in the affected articular cartilage of OA patients and in a mice model of medial meniscal instability-induced OA. Chondrocyte-specific knockdown of Kat7 expression exhibited a protective effect on articular cartilage integrity.
View Article and Find Full Text PDFBiomechanics of the bobsleigh push phase.
J Sports Sci
January 2025
Institute of Biomechanics and Orthopaedics, German Sport University Cologne, Cologne, Germany.
The purpose of this work was to provide a fundamental, in-depth analysis of kinematics and kinetics of the bobsleigh push phase to establish a basis for performance analysis and enhancement. Fifteen elite male athletes performed maximal effort push starts, while ground reaction forces (GRF) and 3D marker trajectories were simultaneously recorded for ground contacts of different sub-sections of the push phase (start acceleration phase: first and second ground contact after the initial push-off from the start block, acceleration phase: 10 m and high-velocity phase: 30 m). To obtain a comprehensive view of the push phase, whole-body kinematics as well as joint kinetics were analysed and compared across the push phase.
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