Background: Haemophilus influenzae requires heme for aerobic growth and possesses multiple mechanisms to obtain this essential nutrient.
Methods: An insertional mutation in tonB was constructed and the impact of the mutation on virulence and fitness in a chinchilla model of otitis media was determined. The tonB insertion mutant strain was significantly impacted in both virulence and fitness as compared to the wildtype strain in this model.
Conclusions: The tonB gene of H. influenzae is required for the establishment and maintenance of middle ear infection in this chinchilla model of bacterial disease.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425130 | PMC |
| http://dx.doi.org/10.1186/1756-0500-5-327 | DOI Listing |
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