Regenerative myogenesis of an extremity regenerating by bilocal distraction osteosynthesis according to Ilizarov has been studied by light end electron microscopy. During the osteosynthesis, the action of the factor of mechanical tension is observed. Muscles elongate because myogenic cells incorporate into muscular fibers in the area of their attachment to dense connective tissues. The data obtained confirm the role of mechanical tension in spatial organization of cells, in morphogenetic and formation processes.
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FASEB J
January 2025
Department of Orthopaedic Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.
Osteoarthritis (OA) is characterized by articular cartilage degeneration, leading to pain and loss of joint function. Recent studies have demonstrated that omega-3 (ω3) polyunsaturated fatty acid (PUFA) supplementation can decrease injury-induced OA progression in mice fed a high-fat diet. Furthermore, PUFAs have been shown to influence the mechanical properties of chondrocyte membranes, suggesting that alterations in mechanosensitive ion channel signaling could contribute to the mechanism by which ω3 PUFAs decreased OA pathogenesis.
View Article and Find Full Text PDFCarbohydr Polym
March 2025
Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai 200241, PR China. Electronic address:
Cellulose foams are renewable and biodegradable materials that are promising substitutes for plastic foams. However, the scale-up fabrication of cellulose foams is severely hindered by technological complexity and cost- and time-consuming drying processes. Here, we developed a facile and robust method to fabricate cellulose foams via oven-drying following surfactant-assisted mechanical foaming of cellulose nanofibers (CNFs).
View Article and Find Full Text PDFBiomech Model Mechanobiol
January 2025
CNR Istituto Officina Dei Materiali, Area Science Park Basovizza, S.S. 14, Km 163,5, 34149, Trieste, Italy.
The organization and dynamics of the spectrin-actin membrane cytoskeleton play a crucial role in determining the mechanical properties of red blood cells (RBC). RBC are subjected to various forces that induce deformation during blood microcirculation. Such forces also regulate membrane tension, leading to Piezo1 channel activation, which is functionally linked to RBC dehydration through calcium influx and subsequent activation of Gardos channels, ultimately resulting in variations in RBC volume.
View Article and Find Full Text PDFBull Math Biol
January 2025
School of Mathematical Sciences, Queensland University of Technology (QUT), Brisbane, Australia.
We propose a simple mathematical model to describe the mechanical relaxation of cells within a curved epithelial tissue layer represented by an arbitrary curve in two-dimensional space. This model generalises previous one-dimensional models of flat epithelia to investigate the influence of curvature for mechanical relaxation. We represent the mechanics of a cell body either by straight springs, or by curved springs that follow the curve's shape.
View Article and Find Full Text PDFInvest Ophthalmol Vis Sci
January 2025
Faculty of Health, Medicine and Social Care, Medical Technology Research Centre, Anglia Ruskin University, Bishops Hall Lane, Chelmsford, United Kingdom.
Purpose: To determine whether lens biomechanical or geometric changes contribute to the decline in the accommodative capacity of the human eye, and to examine any differences in zonular function between different age groups.
Methods: Eighteen finite element whole eye models were developed to simulate the accommodative process. Six models were constructed in each of the two age cohorts, from the fourth and the sixth decades of life using data from ex vivo human lenses.
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