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Are There Effective Methods to Reduce Exposure to House Dust Mite Allergens? A Meta-Analysis of Randomized Clinical Trials.
Int Forum Allergy Rhinol
March 2025
Department of Immunopathology, Division of Biomedical Science, Faculty of Medicine, Medical University of Lodz, Lodz, Poland.
Background: House dust mites (HDMs) are the most common cause of atopic sensitivities and allergic diseases worldwide. Therefore, we decided to conduct a meta-analysis of randomized clinical trials to evaluate the effect of different methods of HDM avoidance.
Methods: PubMed, Web of Science, and the Cochrane Central Register of Controlled Trials databases were searched to find articles of control-compared randomized clinical trials, which investigated the following analyzed outcomes: total amount of dust (g); Der1 (Der p1 plus Der f1) concentrations (µg/g); Der p1 concentrations (µg/g); Der p2 concentrations (µg/g); Der f1 concentrations (µg/g); measurements of peak expiratory flow (PEF) (L/min); respiratory, pulmonary, or nasal symptoms according to various scales, including visual analog scale; exacerbations; Asthma Control Questionnaire score measurements; and change in quality of life scales (overall change, activity change, symptom change, and emotional function change).
Erratum to "Pre-oxygenation using high flow nasal oxygen or face mask oxygen in pregnant people - A prospective randomised controlled crossover non-inferiority study (The HINOP2 study)" [Int J Obstet Anesth 60 (2024) 104236].
Int J Obstet Anesth
March 2025
Department of Critical Care, The University of Melbourne, Parkville, Victoria 3052, Australia; Department of Obstetrics and Gynaecology and Newborn Health, The University of Melbourne, Parkville, Victoria 3052, Australia; Deakin University, Waurn Ponds, Geelong, Australia; Joan Kirner Women's and Children's Hospital, 176 Furlong Rd, St Albans, Victoria 3021, Australia; Brigham and Women's Hospital, 75 Francis Street, Boston, MA, USA.
Multi-omics integration and machine learning identify and validate neutrophil extracellular trap-associated gene signatures in chronic rhinosinusitis with nasal polyps.
Clin Immunol
March 2025
Department of Otorhinolaryngology, Yongchuan Chinese Medicine Hospital Affiliated to Chongqing Medical University, Chongqing 400000, People's Republic of China. Electronic address:
This study aimed to explore the molecular characteristics of neutrophil extracellular traps (NETs) in chronic rhinosinusitis with nasal polyps (CRSwNP). Differentially expressed gene analysis, weighted gene co-expression network analysis, and machine learning algorithms identified three core NETs-associated genes: CXCR4, CYBB, and PTAFR, which were significantly upregulated in CRSwNP patients. The diagnostic performance of these genes was evaluated using receiver operating characteristic (ROC) curves, and their clinical relevance was validated using multicenter data.
View Article and Find Full Text PDFNaMA-Mamba: Foundation model for generalizable nasal disease detection using masked autoencoder with Mamba on endoscopic images.
Comput Med Imaging Graph
March 2025
Academy for Engineering and Technology, Fudan University, Shanghai, 200433, China; Shanghai Key Laboratory of Medical Image Computing and Computer Assisted Intervention, Shanghai, 200032, China. Electronic address:
Artificial intelligence (AI) has shown great promise in analyzing nasal endoscopic images for disease detection. However, current AI systems require extensive expert-labeled data for each specific medical condition, limiting their applications. In this work, the challenge is addressed through two key innovations, the creation of the first large-scale pre-training dataset of nasal endoscopic images, and the development of a novel self-learning AI system specifically designed for nasal endoscopy, named NaMA-Mamba.
View Article and Find Full Text PDFVarenicline Nasal Spray for the Treatment of Dry Eye Disease Following Corneal Collagen Crosslinking.
Ophthalmol Ther
March 2025
Vance Thompson Vision, Bozeman, MT, USA.
Introduction: To evaluate the safety and effectiveness of a varenicline solution nasal spray 0.03 mg (VNS) in reducing signs and symptoms of dry eye disease following corneal collagen cross-linking (CXL).
Methods: Subjects undergoing CXL were randomized to VNS (study) or vehicle (control) twice daily and initiated treatment with VNS 28 days prior to the procedure with continued use for 28 days following the procedure.
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