In insects juvenile hormone (JH) regulates both metamorphosis and reproduction. This lecture focuses on our current understanding of JH action at the molecular level in both of these processes based primarily on studies in the tobacco hornworm Manduca sexta, the flour beetle Tribolium castaneum, the mosquito Aedes aegypti, and the fruit fly Drosophila melanogaster. The roles of the JH receptor complex and the transcription factors that it regulates during larval molting and metamorphosis are summarized. Also highlighted are the intriguing interactions of the JH and insulin signaling pathways in both imaginal disc development and vitellogenesis. Critical actions of JH and its receptor in the timing of maturation of the adult optic lobe and of female receptivity in Drosophila are also discussed.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ygcen.2012.06.001 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Transcriptome analysis identifies key genes in juvenile hormone and ecdysteroid signaling pathways and their roles in regulating reproductive system development of adult Monochamus saltuarius.
Int J Biol Macromol
January 2025
Beijing Key Laboratory for Forest Pest Control, Beijing Forestry University, Beijing 100083, China. Electronic address:
Monochamus saltuarius is an important vector of pinewood nematode in Eurasia with a high reproductive capacity. Endocrine hormones play a key role in insect reproduction. Understanding the mechanism of internal regulation can provide targets for pest control.
View Article and Find Full Text PDFChanges in juvenile hormone titres and differential expression of related genes at different stages of L. female adults supplied with an artificial diet and aphid diet.
Bull Entomol Res
January 2025
Institute of Plant Protection, Guizhou Provincial Academy of Agricultural Sciences, Guiyang, Guizhou, China.
Juvenile hormone (JH) regulates multiple physiological functions in insects including growth, metamorphosis, and reproduction. Juvenile hormone epoxide hydrolase (JHEH) and juvenile hormone esterase (JHE) are degradative enzymes that metabolise JH, and JH receptor (methoprene-tolerant, ) functions in the regulation of female reproduction and vitellogenesis. In this study, JH titres in adult females were determined using ultra high-performance liquid chromatography and tandem mass spectrometry; the JH titres ranged from 0.
View Article and Find Full Text PDFThyroid hormones reversibly inhibit metamorphic development in ophiuroid larvae.
J Exp Biol
January 2025
University of Guelph, 50 Stone Rd E, Guelph, N1G 2M7, Canada.
The timing of metamorphosis and settlement is critical for the survival and reproductive success of marine animals with biphasic life cycles. Thyroid hormones (THs) regulate developmental timing in diverse groups of chordates, including the regulation of metamorphosis in amphibians, teleosts, lancelets, tunicates, and lampreys. Recent evidence suggests a role for TH regulation of metamorphosis outside of the chordates, including echinoderms, annelids, and molluscs.
View Article and Find Full Text PDFand homolog 1 Comediate the Action of Juvenile Hormone/ Signaling Pathway in Vitellogenesis of (J.E. Smith).
J Agric Food Chem
January 2025
College of Plant Protection, Hebei Agricultural University, Baoding, Hebei 071000, P. R. China.
is a major migratory invasive pest and is of global concern. Vitellogenesis, a crucial process for population multiplication in oviparous insects, is regulated by endocrine hormones. In this study, three primary responders to JH signaling, the JH receptor gene , and the downstream transcription factor and , were first cloned and identified.
View Article and Find Full Text PDFHistone deacetylases synergistically regulate juvenile hormone signaling in the yellow fever mosquito, Aedes aegypti.
Insect Biochem Mol Biol
December 2024
Department of Entomology, College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY, 40546, USA. Electronic address:
Article Synopsis
- Effective control of Aedes aegypti mosquitoes is vital to reduce diseases like dengue and zika, focusing on blocking their transition from larvae to adults.
- Research shows that histone deacetylases (HDACs) play a role in regulating juvenile hormone (JH) signaling and metamorphosis, particularly in other insects, but their function in Aedes aegypti is not well understood.
- Knocking down specific HDAC genes increased the expression of a key gene (Kr-h1) involved in larval development, with each HDAC affecting different biological processes in mosquito growth, leading to varied developmental issues.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!