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This case study documents an extraordinary disease progression in a 70-year-old patient diagnosed with metastatic melanoma. The patient's condition advanced to an unusual manifestation characterized by generalized melanosis and melanuria, a rare and foreboding complication of metastatic melanoma. The clinical presentation involved rapid-onset skin darkening, primarily affecting the face and torso, along with darkened urine, marking the onset of melanuria.
View Article and Find Full Text PDFMelanuria in a patient with BRAF-mutant metastatic melanoma of unknown primary: Insights on the pathophysiology, differential diagnosis, prognosis, and treatment.
Am J Med Sci
April 2023
First Department of Internal Medicine, Laikon General Hospital, National and Kapodistrian University of Athens, Greece.
Melanuria is the dark brown discoloration of the urine and an uncommon manifestation in patients with melanoma. It is an ominous sign, usually indicating widespread disease. In this article, through an illustrative case, we discuss the pathophysiological, clinical, and prognostic characteristics of melanuria in melanoma.
View Article and Find Full Text PDF[Mucosal melanoma primary and metastatic cases with urogenital localization in our department].
Orv Hetil
March 2019
Urológiai Klinika, Semmelweis Egyetem, Általános Orvostudományi Kar Budapest, Üllői út 78/B, 1082.
Introduction: Both primary and metastatic cases of mucosal melanoma in urogenital localization are rare tumors. Only 4-5% of all primary melanomas do not arise from the skin. Extracutaneous melanomas have a complex clinical presentation, but these aggressive tumors have a poor prognosis.
View Article and Find Full Text PDFLiver Metastatic Melanoma: a Unique Case with Normal Alkaline Phosphatase and Melanuria.
J Gastrointest Cancer
September 2019
Department of Internal Medicine, University of Texas Medical Branch, 301 University Blvd, Galveston, TX, 77555, USA.
Diffuse cutaneous melanosis: rare complication of metastatic melanoma.
An Bras Dermatol
March 2018
Private practice - Brasília (DF), Brazil.
Diffuse cutaneous melanosis is a rare complication of metastatic melanoma related to a worse prognosis. There are few cases reported in the literature. Its pathogenesis has not been completely elucidated, although studies have suggested certain mechanisms for its occurrence.
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