AI Article Synopsis
- A study analyzed cervico-vaginal secretions from 51 women with different degrees of cervical dysplasia for their mutagenic potential using the Ames test.
- About 23% of samples from women with cervical dysplasia showed significant mutagenic activity, in contrast to only 3% from control samples.
- The findings suggest that the mutagens in these secretions require enzymatic activation, as none showed mutagenicity without the presence of S-9 mix.
Article Abstract
The cervico-vaginal secretions from 51 women with various grades of dysplastic lesions of uterine cervix were assessed for mutagenic potential by Ames test using histidine deficient mutant strain of Salmonella typhimurium TA-98: with S-9 mix. Twenty three per cent of samples from women with cervical dysplasia were found significantly positive (P less than 0.001) for mutagenic activity compared to 3% positive from control. The frequency of mutagenic secretions detected were almost uniform, irrespective of the severity of cervical lesions. None of cervico-vaginal secretions, positive for mutagenicity could revert the tester strain when tested in absence of S-9 mix (liver microsomal enzymes). This indicates that mutagens in cervico-vaginal secretions are effective only when activated enzymatically.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!