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Association between acid-suppressive drugs and risk of psoriasis: retrospective study using Korean National Health Insurance Service-National Sample Cohort.
Korean J Intern Med
January 2025
Department of Dermatology, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon, Korea.
Background/aims: Psoriasis is a common inflammatory skin disorder following non-specific triggers. Involvement of immune system is widely accepted for pathogenesis studies have demonstrated importance of gut microbiota in pathogenesis of inflammatory skin diseases. Proton pump inhibitor (PPI) and histamine-2 receptor antagonist (H2RA) are acid-suppressive drugs widely used for acid related gastrointestinal diseases, and prolonged use has been associated with altered gut microbiota.
View Article and Find Full Text PDFLong-term use of proton pump inhibitors was associated with rapid progression to end stage kidney disease in a Korean nationwide study.
Sci Rep
December 2024
Department of Internal Medicine, Pusan National University School of Medicine, Busan, South Korea.
Proton pump inhibitors (PPIs) are among the most widely used drugs worldwide. However, their influence on the progression of end-stage kidney disease (ESKD) in established chronic kidney disease (CKD) cases is unclear. Using the Korean Health Insurance Review and Assessment database encoded by the Observational Medical Outcomes Partnership-Common Data Model (OMOP-CDM), patients with stage 3 or 4 CKD initiating PPIs or histamine-2 receptor antagonists (H2RAs) for over 90 days were enrolled from 2012 through 2021.
View Article and Find Full Text PDFAccelerated risk of renal disease progression in pre-ESRD patients with proton pump inhibitors use: a nationwide population-based study.
BMC Nephrol
December 2024
Department of Pharmacy, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan.
Background: Although Proton pump inhibitors (PPIs) were mostly prescribed for gastrointestinal (GI) disease widely, there were numerous studies about PPIs and adverse renal outcome. Most evidence was to evaluate the risk of PPIs in patients with normal renal function and in the absence of the moderate to advanced chronic kidney disease (CKD). This study focuses on the accelerated progression of renal function following proton pump inhibitors (PPIs) use, and the increased risks of acute kidney injury (AKI) among moderate to advanced CKD (pre-ESRD) patients.
View Article and Find Full Text PDFOptimizing epidermal growth factor receptor-tyrosine kinase inhibitor treatment in lung cancer: a systematic review and meta-analysis of the influence of gastric acid suppressants.
Transl Lung Cancer Res
November 2024
Division of Pulmonology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.
Background: The introduction of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) has revolutionized advanced non-small cell lung cancer (NSCLC) treatment. However, their efficacy can be compromised by concurrent use of gastric acid suppressants (GASs), such as proton pump inhibitors (PPIs) and histamine 2 receptor antagonists (H2RAs). This study aimed to update the evidence on the impact of GASs on the overall survival (OS) and progression-free survival (PFS) in patients on EGFR-TKI treatment.
View Article and Find Full Text PDFAssociation of acid-suppressive therapy and tuberculosis: A causal or coincidental link to the infection?
Respir Investig
January 2025
Department of Medical Research, Cathay General Hospital, No.280, Sec. 4, Renai Rd., Daan Dist., Taipei, 106438, Taiwan; Division of Infectious Diseases, Department of Internal Medicine, Cathay General Hospital, No.280, Sec. 4, Renai Rd., Daan Dist., Taipei, 106438, Taiwan; Fu Jen Catholic University School of Medicine, No. 510, Zhongzheng Rd., Xinzhuang Dist., New Taipei City, 242062, Taiwan. Electronic address:
Background: Acid-suppressant proton-pump inhibitors (PPI) and histamine-2-receptor antagonists (H2RA) are associated with an increased risk of tuberculosis (TB). However, it remains unclear whether this association is causal or coincidental.
Methods: Patients newly diagnosed with TB between 2000 and 2013 were identified from the Taiwan National Health Insurance Database.
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