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Clinical validation of a prognostic preclinical magnetic resonance imaging biomarker for radiotherapy outcome in head-and-neck cancer.
Radiother Oncol
December 2024
Section for Biomedical Physics, Department of Radiation Oncology, University of Tübingen, Tübingen, Germany; German Cancer Consortium (DKTK), partner site Tübingen, and German Cancer Research Center (DKFZ), Heidelberg, Germany; Cluster of Excellence "Machine Learning", University of Tübingen, Tübingen, Germany. Electronic address:
Purpose: To retrain a model based on a previously identified prognostic imaging biomarker using apparent diffusion coefficient (ADC) values from diffusion-weighted magnetic resonance imaging (DW-MRI) in a preclinical setting and validate the model using clinical DW-MRI data of patients with locally advanced head-and-neck cancer (HNC) acquired before radiochemotherapy.
Material And Methods: A total of 31 HNC patients underwent T2-weighted and DW-MRI using 3 T MRI before radiochemotherapy (35x2Gy). Gross tumor volumes (GTV) were delineated based on T2-weighted and b500 images.
Prognostic value of lymph node metrics in lung squamous cell carcinoma: an analysis of the SEER database.
World J Surg Oncol
December 2024
Department of Hospital Infection Management and Preventive Health Care, Zhejiang Provincial People's Hospital Bijie Hospital, Bijie, 551799, China.
Introduction: Although the Tumor-Node-Metastasis (TNM) staging system is widely used for staging lung squamous cell carcinoma (LSCC), the TNM system primarily emphasizes tumor size and metastasis, without adequately considering lymph node involvement. Consequently, incorporating lymph node metastasis as an additional prognostic factor is essential for predicting outcomes in LSCC patients.
Methods: This retrospective study included patients diagnosed with LSCC between 2004 and 2018 and was based on data from the Surveillance, Epidemiology, and End Results (SEER) database of the National Cancer Institute.
Enclosing 95% confidence area and volume to center of pressure and center of mass in posturography using optimization algorithm and coordinate ascent methods.
Comput Biol Med
December 2024
Department of Kinesiology and Health Education, University of Texas, Austin, 78712, TX, USA.
Balance control has been evaluated using center of pressure (CoP) and center of mass (CoM). One of the most common approaches in stabilometry is enclosing ellipse to 95% of data using principal component analysis (PCA) or covariance methods. However, these methods have limitations, including normality assumption, lack of accuracy, and sample size influence.
View Article and Find Full Text PDFDomino Partial Heart Transplantation.
Am J Transplant
December 2024
Department of Cardiovascular Surgery, Arkansas Children's Hospital, Little Rock, Arkansas. Electronic address:
Heart valve replacement in pediatric cardiothoracic surgery poses problems because conventional heart valve implants do not have the ability to grow. This mandates serial reoperations for implant exchanges until an adult size implant can fit. Partial heart transplantation eliminates these reoperations because the transplanted valves grow.
View Article and Find Full Text PDFThe persistent pool of HIV-1-infected cells is formed episodically during untreated infection.
J Virol
December 2024
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Previous studies have shown that the majority of long-lived cells harboring persistent HIV-1 proviral genomes originates from viruses circulating in the year prior to antiretroviral therapy (ART) initiation, but a smaller proportion originates from viruses circulating much earlier in untreated infection. These observations suggest that discrete biological factors influence the entry and persistence of viruses into the persistent proviral pool, and there may be periods earlier in untreated infection with increased seeding. Therefore, we examined the timing of formation of the long-lived pool of infected cells that persists during ART in seven women (after a median of 5.
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