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GHRH and reproductive systems: Mechanisms, functions, and clinical implications.
Rev Endocr Metab Disord
November 2024
Maimonides Institute for Biomedical Research of Córdoba (IMIBIC), IMIBIC Building. Av. Menéndez Pidal S/N. 14004, Cordoba, Spain.
Article Synopsis
- Growth hormone-releasing hormone (GHRH) is traditionally viewed as a key hormone regulating growth and metabolism through the hypothalamic-pituitary axis, but it's also produced in various peripheral tissues, impacting multiple bodily functions.
- The presence of GHRH and its receptor (GHRH-R) in the reproductive systems of both males and females suggests important roles in gonadal function and reproductive health.
- This review will examine the GHRH/GHRH-R axis's significance in reproductive physiology and discuss how understanding this axis could lead to new treatments for reproductive disorders like infertility, endometriosis, and cancers linked to the reproductive system.
Intussusception of the appendix secondary to endometriosis: a case report.
Surg Case Rep
November 2024
Department of Surgery, Japan Organization of Occupational Health and Safety, Nagasaki Rosai Hospital, Nagasaki, Japan.
Background: Intussusception of the appendiceal endometriosis is rare. Although approximately 200 cases of appendiceal intussusception have been reported in the literature, very few have ever been diagnosed preoperatively. Here, we report the case of intussusception of the appendiceal endometriosis with laparoscopic ileocecal resection.
View Article and Find Full Text PDF[Is there still a place for progesterone receptor modulators in chronic use ?].
Rev Med Liege
September 2024
Service de Gynécologie-Obstétrique, CHU Liège, Belgique.
Selective progesterone receptor modulators (SPRMs) are synthetic steroid compounds that interact with the progesterone receptor, inducing various agonist, antagonist or mixed responses. First identified with mifepristone, they are now represented by ulipristal acetate (UPA), used for emergency contraception and uterine fibroids. Despite a few rare cases of severe hepatic insufficiency, SPRMs offer advantages in the treatment of uterine fibroids, reducing their volume without the hypoestrogenic side-effects of GnRH agonists, thus preserving patients' bone capital and quality of life.
View Article and Find Full Text PDFAn Umbrella Review of Meta-Analyses Evaluating Associations between Human Health and Exposure to Major Classes of Plastic-Associated Chemicals.
Ann Glob Health
August 2024
Minderoo Foundation, Perth, Western Australia, Australia.
Epidemiological research investigating the impact of exposure to plastics, and plastic-associated chemicals, on human health is critical, especially given exponentially increasing plastic production. In parallel with increasing production, academic research has also increased exponentially both in terms of the primary literature and ensuing systematic reviews with meta-analysis. However, there are few overviews that capture a broad range of chemical classes to present a state of play regarding impacts on human health.
View Article and Find Full Text PDFGrowing Role of 3D In Vitro Cell Cultures in the Study of Cellular and Molecular Mechanisms: Short Focus on Breast Cancer, Endometriosis, Liver and Infectious Diseases.
Cells
June 2024
Molecular Medicine Department (DMM), Centre for Health Technologies (CHT), Unità di Ricerca (UdR) INSTM, University of Pavia, 27100 Pavia, Italy.
Over the past decade, the development of three-dimensional (3D) models has increased exponentially, facilitating the unravelling of fundamental and essential cellular mechanisms by which cells communicate with each other, assemble into tissues and organs and respond to biochemical and biophysical stimuli under both physiological and pathological conditions. This section presents a concise overview of the most recent updates on the significant contribution of different types of 3D cell cultures including spheroids, organoids and organ-on-chip and bio-printed tissues in advancing our understanding of cellular and molecular mechanisms. The case studies presented include the 3D cultures of breast cancer (BC), endometriosis, the liver microenvironment and infections.
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