A general diastereoselective method for the addition of dialkylzincs and (E)-di- and (E)-trisubstituted vinylzinc reagents to β-silyloxy aldehydes is presented. This method employs alkyl zinc triflate and nonaflate Lewis acids and affords chelation-controlled products (6:1 to > 20:1 dr).
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401491 | PMC |
| http://dx.doi.org/10.1021/ol301354w | DOI Listing |
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