In the title compound, C(11)H(12)ClNO(3), the dihedral angle between the benzene ring and the amide group is 44.9 (2)°. In the crystal, mol-ecules form inversion dimers via pairs of O-H⋯O hydrogen bonds. These dimers are further linked into sheets parallel to (013) via N-H⋯O hydrogen bonds.
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http://dx.doi.org/10.1107/S1600536812022763 | DOI Listing |
Future Med Chem
January 2025
Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Moga, India.
The study of chalcone-1,2,3-triazole hybrids for anticancer activity is quite a recent area of focus, primarily because of the increasing demand for developing new drugs to treat cancer. The chalcones and 1,2,3-triazole rings in hybrid compounds has recently emerged as a promising strategy for developing novel anticancer agents. The 1,2,3-triazole ring, known for its stability and hydrogen bonding capabilities, enhances the target binding affinity of these hybrids.
View Article and Find Full Text PDFJACS Au
January 2025
Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247667, Uttarakhand, India.
Numerous attempts for organic radical stability mostly entail steric hindrance, spin-delocalization, supramolecular interaction with the host, π-π interactions, and hydrogen bonding. To date, there is no report of single crystals containing a hydroxyl radical (OH). In this work, we have stabilized OH in the crystal, which has been obtained from the filtrate after separating the precipitate of the chromenopyridine radical (DCP(2)) from the reaction mixture.
View Article and Find Full Text PDFChem Sci
January 2025
Department of Chemistry, Seoul National University 1 Gwanak-ro, Gwanak-gu Seoul 08826 Korea
The homochirality of life remains an unresolved scientific question. Prevailing models postulate that homochirality arose through mutual antagonism. In this mechanism, molecules of opposite handedness deactivate each other, amplifying even a small enantiomeric excess into a larger proportion.
View Article and Find Full Text PDFRSC Adv
January 2025
Department of Chemistry, Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahidol University Rama VI Road Bangkok 10400 Thailand
Two series of indolo[1,2-]quinolines (IQs), comprising six 6-trifluoromethylthio indolo[1,2-]quinolines and nine 6-arenesulfonyl indolo[1,2-]quinolines, were screened for their inhibitory activity against EGFR tyrosine kinase (EGFR-TK) using the ADP-Glo™ kinase assay. Among the 15 IQs screened, four compounds exhibited cytotoxic activity against a lung cancer cell line (A549) that was as potent as the known drug afatinib with lower cytotoxicity in Vero cells. In addition, while they displayed cytotoxic activity against a head and neck squamous cell carcinoma cell line (SCC cells), they were inactive against a colorectal cancer cell line (LS174T cells).
View Article and Find Full Text PDFOrg Biomol Chem
January 2025
Department of Chemistry, Birla Institute of Technology and Science, Pilani, Hyderabad Campus, Jawahar Nagar, Hyderabad - 500078, India.
Herein, we report an HFIP-mediated, versatile, sustainable, atom-economical, and regio- and stereoselective hydro-functionalization of ynamides with various -nucleophiles (1 equiv.) such as thiols, thiocarboxylic acids, carbamates, xanthates, and ,-diethyl -hydrogen phosphorothioate to access a wide variety of stereodefined trisubstituted ketene ,-acetals under mild conditions. This protocol requires only HFIP, which plays multiple roles, such as acting as a Brønsted acid to protonate the ynamide regioselectively at the carbon to generate the reactive keteniminium intermediate, stabilizing the intermediate as solvent through H-bonding.
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