In the title compound, C(15)H(13)N(3)O(4), the dihedral angle between the benzene rings is 3.1 (3)°. The mol-ecule displays an E conformation about the C=N bond. In the crystal, mol-ecules are linked via N-H⋯O hydrogen bonds, generating chains that propagate along the b-axis direction. There is also a C-H⋯O inter-action present.
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http://dx.doi.org/10.1107/S1600536812020454 | DOI Listing |
Drug Saf
January 2025
Department of Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Background: Natural language processing (NLP) and machine learning (ML) techniques may help harness unstructured free-text electronic health record (EHR) data to detect adverse drug events (ADEs) and thus improve pharmacovigilance. However, evidence of their real-world effectiveness remains unclear.
Objective: To summarise the evidence on the effectiveness of NLP/ML in detecting ADEs from unstructured EHR data and ultimately improve pharmacovigilance in comparison to other data sources.
Background: Recent research by Da et al. (2023) has demonstrated that non-invasive gamma sensory stimulation can reduce brain white matter atrophy and myelin content loss. The impact on the Corpus Callosum (CC), the brain's largest commissural white matter tract essential for hemispheric connectivity, remains unexplored.
View Article and Find Full Text PDFBackground: Approximately 6.7 million Americans, aged 65 and older, are living with Alzheimer's disease (AD) dementia. Ethnoracial minority populations are at greater risk for AD.
View Article and Find Full Text PDFJ Cogn Neurosci
December 2024
Brown University, Providence, RI.
Each day, humans must parse visual stimuli with varying amounts of perceptual experience, ranging from incredibly familiar to entirely new. Even when choosing a novel to buy at a bookstore, one sees covers they have repeatedly experienced intermixed with recently released titles. Visual exposure to stimuli has distinct neural correlates in the lateral prefrontal cortex (LPFC) of nonhuman primates.
View Article and Find Full Text PDFBackground: Outdoor air pollution is a global issue which poses a significant health risk. Modern neuroimaging techniques have revealed the detrimental impact of air pollution on brain health, in particular the development and progression of neurodegenerative diseases such as Alzheimer's disease (AD). We conducted a systematic review to evaluate the effects of long-term (months to years) exposure to outdoor air pollutants on the development and progression of AD using neuroimaging data.
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