The reaction of nickel(II) thio-cyanate with an excess of pyridazine leads to single crystals of the title compound, [Ni(NCS)(2)(C(4)H(4)N(2))(4)]·2C(4)H(4)N(2). The Ni(II) cations are coordinated by two terminal N-bonded thio-cyanate anions (trans) and four pyridazine ligands in a slightly distorted octa-hedral geometry. The discrete complexes are arranged into layers parallel to the ab plane which are separated by additional non-coordinated pyridazine ligands.
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http://dx.doi.org/10.1107/S1600536812023306 | DOI Listing |
Molecules
December 2024
Institute of Biology, Jan Kochanowski University, 7 Uniwersytecka Str., 25-406 Kielce, Poland.
As a result of drug resistance, many antimicrobial medicines become ineffective, making the infections more difficult to treat. Therefore, there is a need to develop new compounds with antibacterial activity. This role may be played, for example, by metal complexes with carboxylic acids.
View Article and Find Full Text PDFJ Control Release
January 2025
Advanced Pharmaceutics and Drug Delivery Laboratory, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto M5S 3M2, Ontario, Canada. Electronic address:
J Org Chem
December 2024
Laboratory of Physico-Chemistry of Materials and Electrolytes for Energy (PCM2E), Faculty of Sciences and Technologies, University of Tours, Tours 37200, France.
The first efficient Cu(I) catalyzed regioselective C3-(hetero)arylation of 6-(hetero)arylated 1,2,4-triazolo[4,3-]pyridazines has been developed to streamline the synthesis of pharmaceutically important 3,6-diarylated 1,2,4-triazolo[4,3-]pyridazines. This direct (hetero)arylation is compatible with a range of aryl iodides and tolerates a variety of functional groups (23 examples). A series of new 3,6-diarylated 1,2,4-triazolo[4,3-]pyridazines were synthesized with good to excellent yields (up to 98%).
View Article and Find Full Text PDFACS Med Chem Lett
November 2024
Chiesi Farmaceutici S.p.A., Centro Ricerche, Largo Belloli 11/a, 43122 Parma, Italy.
Adv Sci (Weinh)
December 2024
State Key Laboratory of Organometallic Chemistry and Shanghai-Hong Kong Joint Laboratory in Chemical Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, CAS, 345 Lingling Road, Shanghai, 200032, P. R. China.
The transition metal-catalyzed direct coupling reactions involving electron-rich Fischer carbene species are largely underdeveloped and remain a big challenge. Here, a direct coupling reaction of azoles and azine N-oxides is reported with Fischer copper carbene species bearing an α-siloxy group i, which can be in situ generated from acylsilanes catalytically under photoirradiation and redox-neutral conditions. This coupling reaction between electron-rich α-siloxy Fischer Cu-carbene species with hard carbanion nucleophiles may undergo a bimetallic relay process, which is confirmed by the kinetic analysis and in situ NMR analysis.
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