Aggressive classical Kaposi's sarcoma mimicking malignant lymphoma.

Pathol Oncol Res

Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 108 Pyung-Dong, Chongno-Gu, Seoul, 110-746, South Korea.

Published: October 2012

AI Article Synopsis

  • Classical Kaposi's sarcoma is a rare, less aggressive tumor of blood vessel cells that typically progresses slowly, although it can sometimes show more rapid spreading in specific cases, like in HIV/AIDS patients.
  • A 72-year-old woman presented with symptoms such as weight loss and skin eruptions, leading to tests revealing widespread lymph node involvement.
  • The inguinal lymph node biopsy confirmed the diagnosis of Kaposi's sarcoma, despite it resembling a more aggressive form of lymphoma, indicating an atypical presentation of the disease.

Article Abstract

Classical Kaposi's sarcoma is an unusual multifocal neoplasm of vascular endothelial cell origin, and considered a less malignant, slowly-progressing tumor. Although visceral involvement is occasionally seen in HIV/AIDS patients with KS, tumor dissemination to visceral lymph nodes in classical KS is very rare. A 72-year-old woman without any other relevant past medical history presented with anorexia, weight loss, night sweats, and skin eruptions. As the rapid progression of cytopenias and lymphadenopathy were observed, bone marrow biopsy and imaging were performed. Positron emission tomography showed disseminated lymphadenopathy in the cervical, axillary, mediastinal, inguinal, and abdomino-pelvic nodal areas. Inguinal lymph node biopsy was compatible with KS, positive for CD31, CD34, and human herpesvirus-8 by immunohistochemical stain. We report a case of aggressive classical KS mimicking aggressive malignant lymphoma.

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Source
http://dx.doi.org/10.1007/s12253-012-9545-5DOI Listing

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