Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1056/NEJMc1204669 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Catatonia is one of the most severe psychiatric syndromes, and clinical symptoms and etiology are very heterogeneous. When accompanied by autonomic instability and hyperthermia it’s termed malignant catatonia, which left untreated is associated with significant morbidity and mortality. First-line treatment is high dose benzodiazepines, followed by electroconvulsive therapy (ECT), in case of non-response.
View Article and Find Full Text PDFonitoring drug fficacy through ulti-mics esearch initiative in lzheimer's isease (MEMORI-AD): A protocol for a multisite exploratory prospective cohort study on the drug response-related clinical, genetic, microbial and metabolomic signatures in Filipino patients with Alzheimer's disease.
BMJ Open
November 2024
Mutli-Omics Research Program for Health, University of the Philippines Manila College of Medicine, Manila, Metro Manila, Philippines.
Introduction: Dementia is one of the leading causes of disability among older people aged 60 years and above, with majority eventually being diagnosed with Alzheimer's disease (AD). Pharmacological agents approved for dementia include acetylcholinesterase enzyme (AChE) inhibitors like rivastigmine, donepezil and galantamine and the N-methyl-D-aspartate (NMDA) receptor antagonist memantine, prescribed as monotherapy or in combination with each other, depending on the severity of disease. There is currently no available study demonstrating the clinical response to these drugs for AD in the Filipino population.
View Article and Find Full Text PDFCerebrolysin in Patients Diagnosed with Subarachnoid Hemorrhage-The Results of an Observational Cohort Study.
Biomedicines
October 2024
Department of Specialist Nursery, Pomeranian Medical University, Zolnierska Str. 48, 71-210 Szczecin, Poland.
Subarachnoid hemorrhage (SAH) is associated with high mortality and a high level of disability. Progress in surgical and endovascular techniques has lowered the mortality rate in patients with SAH. However, many patients are left with neurological impairment.
View Article and Find Full Text PDFDiscontinuation of Cholinesterase Inhibitors Following Initiation of Memantine and Admission to Long-Term Care Among Older Adults.
JAMA Netw Open
November 2024
Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts.
Importance: Discontinuing cholinesterase inhibitors when initiating memantine in patients with dementia may be reasonable to reduce treatment burden, costs, and the risk of adverse drug events.
Objective: To assess the association of cholinesterase inhibitor discontinuation on long-term care institutionalization among older adults with dementia who initiate memantine.
Design, Setting, And Participants: This retrospective propensity score-matched cohort study used Medicare claims data from January 2014 to December 2019.
Low Dose Amantadine and Escitalopram in Progressive Supranuclear Palsy and Multiple System Atrophy.
Ann Neurosci
February 2024
Department of Geriatric Mental Health, King George's Medical University, Lucknow, Uttar Pradesh, India.
Progressive supranuclear palsy (PSP) and multiple system atrophy (MSA) are less responsive to usual antiparkinsonian drugs. To assess the treatment outcome of the combination of low-dose amantadine and escitalopram in the study population. A retrospective study of PSP and MSA patients from June 2021 to December 2022 treated with the dose of amantadine 100 mg and escitalopram 5 mg per day with a follow-up of 2 months at a tertiary care centre in India.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!