A collision tumour in ovary comprising a small ovoid embryoid mature teratoma in the surface wall of large mucinous cyst adenoma is reported in a 36-year-old female and its pathogenesis is discussed. The oval teratoid mass externally to the mucinous cyst lining did not show any columnar epithelial or mucin-secreting cyst. Findings suggested that the mature embryoid teratoma originated from ovarian germ cell rest in the surface wall of the cyst adenomatous neoplasm. Another possibility could be that the mature embryoid teratoma resulted from parthenogenesis of ovum together with the mucinous adenoma cysts by epithelial metaplasia of the follicular lining.
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http://dx.doi.org/10.1136/bcr.07.2010.3205 | DOI Listing |
Toxicol Appl Pharmacol
January 2025
Mechanistic Toxicology Branch, Division of Translational Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, United States of America. Electronic address:
Modeling brain development and function is challenging due to complexity of the organ. Human pluripotent stem cell (PSC)-derived brain-like organoids provide new tools to study the human brain. Compared with traditional in vivo toxicological studies, these 3D models, together with 2D cellular assays, enhance our understanding of the mechanisms of developmental neurotoxicity (DNT) during the early stages of neurogenesis and offer numerous advantages including a rapid, cost-effective approach for understanding compound mechanisms and assessing chemical safety.
View Article and Find Full Text PDFJ Vis Exp
December 2024
Department of Biomedical Engineering, Columbia University;
Vascular organoids derived from human induced pluripotent stem cells (hiPSCs) recapitulate the cell type diversity and complex architecture of human vascular networks. This three-dimensional (3D) model holds substantial potential for vascular pathology modeling and in vitro drug screening. Despite recent advances, a key technical challenge remains in reproducibly generating organoids with consistent quality, which is crucial for downstream assays and applications.
View Article and Find Full Text PDFToxicol Mech Methods
December 2024
Laboratory of Clinical and Experimental Toxicology, and Pavia Poison Center-National Toxicology Information Center, Toxicology Unit, Istituti Clinici Scientifici Maugeri IRCCS, Pavia, Italy.
The inherent adaptability of human mesenchymal stromal cells (hMSCs) to differentiate into neural lineages provides a valuable resource for investigating potential neurotoxicity in humans. By harnessing the ability of hMSCs to transform into astrocytes, we can evaluate the effects of various agents on these vital cells. Our protocol employs hMSCs sourced from umbilical cord tissue, ensuring a readily available supply of high-quality cells.
View Article and Find Full Text PDFCells
November 2024
Department of Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA.
Stem Cell Res Ther
November 2024
Siriraj Center for Regenerative Medicine, Research Department, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, 10700, Thailand.
Background: Adoptive immunotherapy using natural killer (NK) cells has attracted considerable interest in numerous clinical trials targeting both hematological and solid tumors. Traditionally, NK cells are primarily derived from either peripheral blood (PB) or umbilical cord blood (UCB). However, these methods can lead to variability and heterogeneity within the NK cell population.
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