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Effect of cobalt ions doping on morphology and electrochemical properties of hydroxyapatite coatings for biomedical applications.
Sci Rep
January 2025
Department of Physical Chemistry, Faculty of Chemistry, University of Tabriz, 29 Bahman Blvd., Tabriz, Iran.
Hydroxyapatite (HA) is an engineered biomaterial that closely resembles the hard tissue composition of humans. Biological HA is commonly non-stoichiometric and features lower crystallinity and higher solubility than stoichiometric HA. The chemical compositions of these biomaterials include calcium (Ca), phosphorus (P), and trace amounts of various ions such as magnesium (Mg), zinc (Zn), and strontium (Sr).
View Article and Find Full Text PDFDevelopment of hybrid bionanocomposites of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) with zinc oxide and silicon-doped hydroxyapatite nanocrystals and machine learning for predicting dynamic mechanical properties.
Int J Biol Macromol
December 2024
Yıldız Technical University, Department of Bioengineering, Davutpasa Campus, 34210 Esenler, İstanbul, Turkey.
The development of hybrid materials that integrate bioactive and antimicrobial properties within a biodegradable and biocompatible polymer matrix is a key focus in current biomedical research and applications. A significant research gap exists in the field of PHBV nanocomposites, particularly concerning those that simultaneously incorporate both ZnO and HAP particles. This study focuses on the fabrication and characterization of innovative hybrid bionanocomposites composed of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) combined with zinc oxide (ZnO) and silicon-doped hydroxyapatite (SiHAP) nanocrystals.
View Article and Find Full Text PDFDesign and characterization of a ROS-responsive antibacterial composite hydrogel for advanced full-thickness wound healing.
Int J Biol Macromol
December 2024
School of Life Sciences, Northwestern Polytechnical University, Xi'an 710072, China. Electronic address:
Full-thickness skin wounds remian a significant and pressing challenge. In this study, we introduce a novel composite hydrogel, CS + GA + Zn-HA. This hydrogel is formulated by incorporating 1 % (1 g/100 mL) of bioactive Zinc-substituted hydroxyapatite nanoparticles (Zn-HA) and 0.
View Article and Find Full Text PDFZinc-doped hydroxyapatite loaded chitosan gelatin nanocomposite scaffolds as a promising platform for bone regeneration.
Biomed Mater
January 2025
Department of Paper Technology, IIT Roorkee, Saharanpur 247001, India.
The advancement in the arena of bone tissue engineering persuades us to develop novel nanocomposite scaffolds in order to improve antibacterial, osteogenic, and angiogenic properties that show resemblance to natural bone extracellular matrix. Here, we focused on the development of novel zinc-doped hydroxyapatite (ZnHAP) nanoparticles (1, 2 and 3 wt%; size: 50-60 nm) incorporated chitosan-gelatin (CG) nanocomposite scaffold, with an interconnected porous structure. The addition of ZnHAP nanoparticles decreases the pore size (∼30 µm) of the CG scaffolds.
View Article and Find Full Text PDF3D-printed zinc oxide nanoparticles modified barium titanate/hydroxyapatite ultrasound-responsive piezoelectric ceramic composite scaffold for treating infected bone defects.
Bioact Mater
March 2025
Department of Oral, Plastic and Aesthetic Surgery, Hospital of Stomatology, Jilin University, Changchun, 130021, China.
Clinically, infectious bone defects represent a significant threat, leading to osteonecrosis, severely compromising patient prognosis, and prolonging hospital stays. Thus, there is an urgent need to develop a bone graft substitute that combines broad-spectrum antibacterial efficacy and bone-inductive properties, providing an effective treatment option for infectious bone defects. In this study, the precision of digital light processing (DLP) 3D printing technology was utilized to construct a scaffold, incorporating zinc oxide nanoparticles (ZnO-NPs) modified barium titanate (BT) with hydroxyapatite (HA), resulting in a piezoelectric ceramic scaffold designed for the repair of infected bone defects.
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