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Nervous system contributions to small cell lung cancer: Lessons from diverse oncological studies.
Biochim Biophys Acta Rev Cancer
December 2024
Thoracic Oncology Ward, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China; Department of Radiotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu, China; Laboratory of Clinical Cell Therapy, West China Hospital, Sichuan University, Chengdu, China. Electronic address:
The nervous system plays a vital role throughout the entire lifecycle and it may regulate the formation, development and metastasis of tumors. Small cell lung cancer is a typical neuroendocrine tumor, and it is naturally equipped with neurotropism. In this review, we firstly summarize current preclinical and clinical evidence to demonstrate the reciprocal crosstalk among the nervous system, tumor, and tumor microenvironment in various ways, including neurotransmitter-receptor pathways, innervations of nerve fibers, different types of synapse formation by neurons, astrocytes, and cancer cells, neoneurogenesis.
View Article and Find Full Text PDFNonoperative management for disseminated spinal blastomycosis with extensive lytic destruction in a 35-year-old male: illustrative case.
J Neurosurg Case Lessons
December 2024
Department of Neurosurgery, University of Mississippi Medical Center, Jackson, Mississippi.
Background: The authors describe the case of a 35-year-old male who presented with back pain and painful masses on his upper extremities. He had a known sacral lesion identified 1 year prior at an outside facility, suspected to be coccidioidomycosis on biopsy, but the workup was not completed because the patient left against medical advice and was lost to follow-up. Computed tomography (CT) and magnetic resonance imaging revealed lytic destructive lesions involving the calvaria, thoracolumbar spine, and sacrum, concerning for an active and disseminated infection.
View Article and Find Full Text PDFRinderpest and peste des petits ruminants (PPR) are two closely related viral diseases caused by viruses belonging to the genus Morbillivirus and affecting ruminants. Both diseases are notifiable to the World Organisation for Animal Health (WOAH) due to their high contagiosity and economic importance. International collaboration and scientific developments have led to the eradication of rinderpest, which was celebrated in 2011, 250 years after the first veterinary school was created in Lyon.
View Article and Find Full Text PDFIn Situ Transmission Electron Microscopy of Electrocatalyst Materials: Proposed Workflows, Technical Advances, Challenges, and Lessons Learned.
Small Methods
December 2024
Department of Chemical Engineering, McMaster University, Hamilton, ON, L8S 4L7, Canada.
In situ electrochemical liquid phase transmission electron microscopy (LP-TEM) measurements utilize micro-chip three-electrode cells with electron transparent silicon nitride windows that confine the liquid electrolyte. By imaging electrocatalysts deposited on micro-patterned electrodes, LP-TEM provides insight into morphological, phase structure, and compositional changes within electrocatalyst materials under electrochemical reaction conditions, which have practical implications on activity, selectivity, and durability. Despite LP-TEM capabilities becoming more accessible, in situ measurements under electrochemical reaction conditions remain non-trivial, with challenges including electron beam interactions with the electrolyte and electrode, the lack of well-defined experimental workflows, and difficulty interpreting particle behavior within a liquid.
View Article and Find Full Text PDFLessons learned from the experiences of newly qualified therapeutic radiography students who transitioned to work during the Covid-19 pandemic.
Radiography (Lond)
December 2024
Cardiff University School of Healthcare Sciences, Ty Dewi Sant, University Hospital Wales, Heath Campus, Cardiff CF14 4XN, UK.
Introduction: The Covid-19 pandemic raised profound questions regarding healthcare values and responsibility for managing collective and individual needs. This context presents a unique opportunity to explore the experiences of newly qualified therapeutic radiographers transitioning to work.
Method: An interpretivist qualitative design used one-to-one, semi-structured interviews.
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