Recent research has demonstrated that knowledge of real-world eventsplays an important role inguiding online language comprehension. The present study addresses the scope of event knowledge activation during the course of comprehension, specifically investigating whether activation is limited to those knowledge elements that align with the local linguistic context.The present study addresses this issue by analyzing event-related brain potentials (ERPs) recorded as participants read brief scenariosdescribing typical real-world events. Experiment 1 demonstratesthat a contextually anomalous word elicits a reduced N400 if it is generally related to the described event, even when controlling for the degree of association of this word with individual words in the preceding context and with the expected continuation. Experiment 2 shows that this effect disappears when the discourse context is removed.These findings demonstrate that during the course of incremental comprehension, comprehenders activate general knowledge about the described event, even at points at which this knowledge would constitute an anomalous continuation of the linguistic stream. Generalized event knowledge activationcontributes to mental representations of described events, is immediately available to influence language processing, and likely drives linguistic expectancy generation.
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http://dx.doi.org/10.1016/j.jml.2012.01.001 | DOI Listing |
Sci Rep
January 2025
Department of Horticulture, Washington State University Northwestern Washington Research and Extension Center, Mount Vernon, WA, 98221, USA.
Biostimulants are an emerging and innovative class of products that may mitigate the adverse effects of extreme heat, but research on their efficacy in fruit crops is limited. This study addressed this knowledge gap by evaluating the performance of three biostimulants, FRUIT ARMOR™, Optysil®, and KelpXpress™ [active ingredients glycine betaine, silicon, and kelp (Ascophyllum nodosum) extract, respectively] applied to three raspberry genotypes exposed to high temperatures (T ≥ 35 °C/day) inside a glasshouse. 'Meeker' consistently maintained high chlorophyll fluorescence (F/F) and photosynthesis under control and biostimulant treatments.
View Article and Find Full Text PDFJ Immunother Cancer
January 2025
Investigational Cancer Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA
Purpose: BMS-986299 is a first-in-class, NOD-, LRR-, and pyrin-domain containing-3 (NLRP3) inflammasome agonist enhancing adaptive immune and T-cell memory responses.
Materials And Methods: This was a phase-I (NCT03444753) study that assessed the safety and tolerability of intra-tumoral BMS-986299 monotherapy (part 1A) and in combination (part 1B) with nivolumab, and ipilimumab in advanced solid tumors. Reported here are single-center results.
Sci Total Environ
January 2025
Department of Microbiology, Pondicherry University, Kalapet, Puducherry 605014, India. Electronic address:
Climate change-induced rise in sea surface temperatures has led to an increase in the frequency and severity of coral bleaching events, ultimately leading to the deterioration of coral reefs, globally. However, the reef-building corals have an inherent capacity to acclimatize to thermal stress on pre-exposure to high temperatures by altering their endosymbiotic Symbiodiniaceae community composition towards a thermal tolerant composition. This reorganisation may become an important tool in coral's resilience to rapid environmental change.
View Article and Find Full Text PDFCurr Opin Struct Biol
January 2025
Institute of Structural and Molecular Biology, School of Natural Sciences, Birkbeck College, Malet Street, London, WC1E 7HX, United Kingdom; Institute of Structural and Molecular Biology, Division of Biosciences, University College London, Gower Street, WC1E 6BT, United Kingdom. Electronic address:
Bacterial conjugation is the unidirectional transfer of DNA (often plasmids, but also other mobile genetic elements, or even entire genomes), from a donor cell to a recipient cell. In Gram-negative bacteria, it requires the formation of three complexes in the donor cell: i-a large, double-membrane-embedded transport machinery called the Type IV Secretion System (T4SS), ii-a long extracellular tube, the conjugative pilus, and iii-a DNA-processing machinery termed the relaxosome. While knowledge has expanded regarding molecular events in the donor cell, very little is known about the machinery involved in DNA transfer into the recipient cell.
View Article and Find Full Text PDFAm J Transl Res
December 2024
Trauma Medicine Center, West China Hospital, Sichuan University Chengdu, Sichuan, China.
Objective: To investigate the application value of nursing signs in the risk management of elderly fracture patients.
Methods: A total of 88 elderly fracture patients admitted to West China Hospital between April 2021 and August 2022, along with 12 nursing staff members, were selected as study participants. The clinical data of these patients were retrospectively analyzed, and the patients were divided into two groups based on the nursing management strategy employed.
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