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A review on toxic epidermal necrolysis-like superficial wound lesions: Issue and challenge on 10 clinical entities.
Int Wound J
December 2024
Student Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran.
Toxic epidermal necrolysis (TEN) is a severe skin reaction caused by extensive epidermal and mucosal necrosis. This clinical phenomenon is known as an acute syndrome of apoptotic pan-epidermolysis (ASAP). The ASAP phenomenon is observed in conditions that mimic TEN, highlighting the challenge in distinguishing these conditions.
View Article and Find Full Text PDFStevens-johnson Syndrome and Toxic Epidermal Necrolysis: An Overview of Diagnosis, Therapy Options and Prognosis of Patients.
Recent Adv Inflamm Allergy Drug Discov
November 2023
Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala 133 207, Haryana, India.
Article Synopsis
- Stevens-Johnson Syndrome (SJS) and Toxic-Epidermal Necrolysis (TEN) are serious, medication-induced skin conditions affecting mucus membranes and the epidermis, with annual incidence rates of about 1 to 2 per million people; SJS has a mortality rate of 1-5%, while TEN has a much higher rate of 25-35%.
- Both conditions are characterized by severe skin detachment, mucocutaneous discomfort, and potential long-term effects on survivors, particularly in the elderly, who may experience reduced quality of life and life expectancy.
- The majority of cases are caused by specific drugs, including carbamazepine and sulfonamides,
Childhood epidermal necrolysis and erythema multiforme major: a multicentre French cohort study of 62 patients.
J Eur Acad Dermatol Venereol
October 2021
Dermatology Department, AP-HP, CHU Necker-Enfants Malades, Paris Centre University, Paris, France.
Introduction: The distinction between epidermal necrolysis [EN; including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and overlap syndrome] and erythema multiforme major (EMM) in children is confusing. We aimed to better describe and compare these entities.
Materials And Methods: This French retrospective multicentre study included children ≤18 years old referred for EN or EMM between 1 January 2008 and 1 March 2019.
Clinical and histologic features of Mycoplasma pneumoniae-related erythema multiforme: A single-center series of 33 cases compared with 100 cases induced by other causes.
J Am Acad Dermatol
July 2018
Dermatology Department, Assistance Publique Hôpitaux de Paris (AP-HP), Henri Mondor Hospital, Créteil, France; Epidémiologie en Dermatologie et Evaluation des Thérapeutiques, Université Paris-Est Créteil (UPEC) Val de Marne, Créteil, France; Referral Center for Toxic Bullous Diseases, AP-HP, Henri Mondor Hospital, Créteil, France; UPEC, Créteil, France.
Background: Mycoplasma pneumoniae infection has been documented in erythema multiforme (EM) and Stevens-Johnson syndrome-toxic epidermal necrosis (SJS-TEN). Clinical aspects of M pneumoniae-related EM have been poorly described in the literature.
Objective: To highlight differences between M pneumoniae EM and non-M pneumoniae EM.
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