Since its foundation in the beginning of this century, the Vaugirard hospital of which the origin is briefly recalled, found its way towards digestive surgery and gastroenterology. This induced the creation, 35 years ago, of the Vaugirard Radio-anatomo-clinical Confrontations, only dedicated to digestive pathology.
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Circulating Polyploid Giant Cancer Cells, a Potential Prognostic Marker in Patients with Carcinoma.
Int J Mol Sci
September 2024
Rarecells Faculté de Médecine Necker, 160 Rue de Vaugirard, 75015 Paris, France.
Polyploid Giant Cancer Cells (PGCCs) have been recognized as tumor cells that are resistant to anticancer therapies. However, it remains unclear whether their presence in the bloodstream can be consistently detected and utilized as a clinical marker to guide therapeutic anticancer regimens. To address these questions, we conducted a retrospective study involving 228 patients diagnosed with six different types of carcinomas (colon, gastric, NSCLC, breast, anal canal, kidney), with the majority of them (70%) being non-metastatic.
View Article and Find Full Text PDFTiming and location dictate monocyte fate and their transition to tumor-associated macrophages.
Sci Immunol
July 2024
Institut Gustave Roussy, INSERM U1015, Bâtiment de Médecine Moléculaire 114 rue Edouard Vaillant, 94800 Villejuif, France.
Tumor-associated macrophages (TAMs) are a heterogeneous population of cells whose phenotypes and functions are shaped by factors that are incompletely understood. Herein, we asked when and where TAMs arise from blood monocytes and how they evolve during tumor development. We initiated pancreatic ductal adenocarcinoma (PDAC) in inducible monocyte fate-mapping mice and combined single-cell transcriptomics and high-dimensional flow cytometry to profile the monocyte-to-TAM transition.
View Article and Find Full Text PDF[Portrait of Tiphaine Goulenok, hospital practitioner in internal medicine at Hôpital Bichat, Paris, by Grégoire Martin de Frémont].
Rev Med Interne
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Inborn Errors of Immunity in Hidradenitis Suppurativa: a New Lead for HS Genetics?
J Clin Immunol
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INSERM UMR 1163, Laboratory of Genetic Skin Diseases, Imagine Institute, 75015, Paris, France.
Prevalence and risk factors of toxigenic asymptomatic carriage in 11 French hospitals.
Front Med (Lausanne)
July 2023
Unité de prévention du risque infectieux, Hôpital Saint Antoine, Paris, France.
Article Synopsis
- The incidence of Clostridium difficile infection (CDI) has risen over the past 20 years, with asymptomatic carriers potentially serving as important reservoirs in healthcare settings.* -
- A study conducted from September 2019 to January 2020 in 11 hospitals in Paris included 2,389 patients over 3 years old, revealing a 3.2% asymptomatic carriage rate of toxigenic strains of CDI.* -
- Key factors associated with increased asymptomatic carriage were co-carriage of multidrug-resistant organisms and previous CDI history, while consuming raw milk products appeared to lower the risk.*
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