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| http://dx.doi.org/10.1038/bjc.2012.119 | DOI Listing |
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Evaluation of Bayesian Maximum Entropy Data Fusion Approaches to Estimate Styrene, Benzene, Toluene, Ethylbenzene, and Xylenes and to Inform Epidemiological Analyses in the US Gulf States.
Environ Sci Technol
January 2025
Department of Environmental Sciences & Engineering, University of North Carolina, Chapel Hill, North Carolina 27599, United States.
The Gulf States are home to industries emitting styrene, benzene, toluene, ethylbenzene, and xylenes (SBTEX). Presently, adverse health effects of ambient SBTEX exposure in highly polluted regions, such as the Gulf States, must be evaluated. Epidemiologists, however, are limited by inadequate estimates of ambient SBTEX.
View Article and Find Full Text PDFInhibition of METTL14 overcomes CDK4/6 inhibitor resistance driven by METTL14-m6A-E2F1-axis in ERα-positive breast cancer.
J Nanobiotechnology
January 2025
State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Biotechnology Center, School of Pharmacy, The Fourth Military Medical University, 169 Changle West Road, 710032, Xi'an, People's Republic of China.
CDK4/6i, the first-line drug for treating ERα-positive breast cancer, significantly improves clinical outcomes. However, CDK4/6i resistance often develops and remains a major hurdle, and the underlying mechanisms remain challenging to fully investigate. Here, we used Genome-wide CRISPR/Cas9 library screening combined with single-cell sequencing to screen for molecules mediating CDK4/6i resistance and identified METTL14 as a determinant of CDK4/6i sensitivity.
View Article and Find Full Text PDFAnxiety and burnout in infectious disease nurses: the role of perceived stress and resilience.
BMC Nurs
January 2025
Department of Clinical Nutrition, School of Medicine, Chongqing University Cancer Hospital, Chongqing University, Chongqing, China.
Background: Nurses serving in infectious disease ward represent a distinct occupational group that has attracted considerable attention following epidemic outbreaks. However, prior to this study, no research had delved into the underlying mechanism linking anxiety to burnout symptoms among infectious disease nurses. This study aimed to explore investigate the association between anxiety and burnout among nurses working in such environments and scrutinized the mediating role of perceived stress and the moderating influence of resilience on the principal relationship.
View Article and Find Full Text PDFBlood DNA virome associates with autoimmune diseases and COVID-19.
Nat Genet
January 2025
Department of Statistical Genetics, Osaka University Graduate School of Medicine, Suita, Japan.
Aberrant immune responses to viral pathogens contribute to pathogenesis, but our understanding of pathological immune responses caused by viruses within the human virome, especially at a population scale, remains limited. We analyzed whole-genome sequencing datasets of 6,321 Japanese individuals, including patients with autoimmune diseases (psoriasis vulgaris, rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), pulmonary alveolar proteinosis (PAP) or multiple sclerosis) and coronavirus disease 2019 (COVID-19), or healthy controls. We systematically quantified two constituents of the blood DNA virome, endogenous HHV-6 (eHHV-6) and anellovirus.
View Article and Find Full Text PDF[Not Available].
Tunis Med
December 2024
Department of Epidemiology and Preventive Medicine, CHU Tlemcen, Faculty of Medicine, Abou Bekr Belkaid University, 13000 Tlemcen, Algeria.
Introduction: Clinical Reasoning Learning (CRL) is one of the most important methods of active learning in medicine. This instruction is designed for small groups of students.
Objectives And Methods: We conducted a prospective descriptive study with the primary goal of adapting this instruction for large groups of students.
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