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Integrating RNA-seq and scRNA-seq to explore the prognostic features and immune landscape of exosome-related genes in breast cancer metastasis.
Ann Med
December 2025
Department of Neurosurgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, PR China.
Objective: This study aims to explore the role of exosome-related genes in breast cancer (BRCA) metastasis by integrating RNA-seq and single-cell RNA-seq (scRNA-seq) data from BRCA samples and to develop a reliable prognostic model.
Methods: Initially, a comprehensive analysis was conducted on exosome-related genes from the BRCA cohort in The Cancer Genome Atlas (TCGA) database. Three prognostic genes (JUP, CAPZA1 and ARVCF) were identified through univariate Cox regression and Lasso-Cox regression analyses, and a metastasis-related risk score model was established based on these genes.
Predicting User Engagement in Health Misinformation Correction on Social Media Platforms in Taiwan: Content Analysis and Text Mining Study.
J Med Internet Res
January 2025
Institute of Learning Sciences and Technologies, National Tsing Hua University, Hsinchu, Taiwan.
Background: Health misinformation undermines responses to health crises, with social media amplifying the issue. Although organizations work to correct misinformation, challenges persist due to reasons such as the difficulty of effectively sharing corrections and information being overwhelming. At the same time, social media offers valuable interactive data, enabling researchers to analyze user engagement with health misinformation corrections and refine content design strategies.
View Article and Find Full Text PDFDigital Health Solutions for Cardiovascular Disease Prevention: Systematic Review.
J Med Internet Res
January 2025
Centre for Research in Media and Communication, Faculty of Social Sciences and Humanities, Universiti Kebangsaan Malaysia, Selangor, Malaysia.
Background: Cardiovascular disease (CVD) is a major global health issue, with approximately 70% of cases linked to modifiable risk factors. Digital health solutions offer potential for CVD prevention; yet, their effectiveness in covering the full range of prevention strategies is uncertain.
Objective: This study aimed to synthesize current literature on digital solutions for CVD prevention, identify the key components of effective digital interventions, and highlight critical research gaps to inform the development of sustainable strategies for CVD prevention.
Systematic review of the needs and health-related quality of life domains relevant to people surviving cancer in Europe.
Qual Life Res
January 2025
Health Services Research Group, Hospital del Mar Research Institute, Barcelona, Spain.
Purpose: To systematically review qualitative studies on outcomes, needs, experiences, preferences, concerns and health-related quality of life (HRQoL) of people surviving cancer in Europe in the last decade.
Methods: Protocol registered ( https://www.crd.
Prescriptions (Rx) for Prevention: Clinical Tools for Integrating Environmental Health into Pediatric Clinical Care.
J Public Health Manag Pract
January 2025
Department of Environmental Medicine and Public Health (Mr Bland, Dr Zajac, Ms Guel, Dr Pendley, Dr Galvez, Dr Sheffield), Icahn School of Medicine at Mount Sinai, New York, New York; Harvard Kenneth C. Griffin Graduate School of Arts and Sciences (Mr Wilson), Boston, Massachusetts; Environmental Research and Translation for Health (EaRTH) Center (Ms Charlesworth), University of California, San Francisco, California; Community Engagement Core, Environmental Health Sciences Center at Department of Environmental Medicine (Dr Korfmacher), University of Rochester Medical Center, Rochester, New York; Pediatric Environmental Health and Cincinnati Children's Hospital Medical Center (Dr Newman), Cincinnati, Ohio; Philadelphia Regional Center for Children's Environmental Health, Center of Excellence in Environmental Toxicology, Perelman School of Medicine (Dr Howarth), University of Pennsylvania, Philadelphia, Pennsylvania; and Division of Academic General Pediatrics, Children's Hospital at Montefiore (Dr Balk), Albert Einstein College of Medicine, Bronx, New York.
The integration of environmental health (EH) into routine clinical care for children is in its early stages. The vision of pediatric EH is that all clinicians caring for children are aware of and able to help connect families to needed resources to reduce harmful environmental exposures and increase health-enhancing ones. Environmental exposures include air pollution, substandard housing, lead, mercury, pesticides, consumer products chemicals, drinking water contaminants, industrial facility emissions and, increasingly, climate change-related extreme weather and heat events.
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